FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3096688043> ?p ?o ?g. }

• W3096688043 endingPage "3" @default.
• W3096688043 startingPage "3" @default.
• W3096688043 abstract "Purpose Sigma 1 receptor is a novel therapeutic target for retinal disease. Its activation, using a high-affinity, high-specificity ligand (+)-pentazocine ((+)-PTZ), rescues photoreceptor cells in the rd10 mouse model of RP. Here, we asked whether the robust retinal neuroprotective properties of (+)-PTZ are generalizable to SA4503 and PRE084, two other high-affinity sigma 1 receptor ligands. Methods We treated 661W cells with SA4503 or PRE084. Cell viability, oxidative stress, and expression of Nrf2 and NRF2-regulated antioxidant genes (Nqo1, Cat, and Sod1) were assessed. Rd10 mice were administered SA4503 (1 mg/kg), PRE084 (0.5 mg/kg), or (+)-PTZ (0.5 mg/kg). Visual acuity, retinal architecture, and retinal electrophysiologic function were measured in vivo and retinal structure was assessed histologically. Results Similar to (+)-PTZ, SA4503 and PRE084 improved cell viability, attenuated oxidative stress, and increased Nrf2, Nqo1 and Cat expression. Although treatment of rd10 mice with (+)-PTZ improved visual acuity, increased outer retinal thickness, and improved photopic a- and b-wave responses compared with nontreated rd10 mice, treatment with SA4503 or PRE084 did not. The number of photoreceptor nuclei/100 µm retinal length in SA4503- and PRE084-treated rd10 mice (approximately 11/100) did not differ significantly from nontreated rd10 mice, whereas (+)-PTZ-treated mice had significantly more nuclei (approximately 22/100 µm). Conclusions Cell survival and gene regulation experiments yielded similar outcomes when SA4503, PRE084, or (+)-PTZ were conducted in vitro, however neither SA4503 or PRE084 afforded in vivo protection in the severe rd10 retinopathy model comparable to (+)-PTZ. Despite all three compounds demonstrating the potential to activate sigma 1 receptor, the retinal neuroprotective properties of the three ligands differ significantly." @default.
• W3096688043 created "2020-11-09" @default.
• W3096688043 creator A5009235404 @default.
• W3096688043 creator A5044459542 @default.
• W3096688043 creator A5080349207 @default.
• W3096688043 creator A5081262873 @default.
• W3096688043 date "2020-11-02" @default.
• W3096688043 modified "2023-09-24" @default.
• W3096688043 title "Comparison of Sigma 1 Receptor Ligands SA4503 and PRE084 to (+)-Pentazocine in the <i>rd10</i> Mouse Model of RP" @default.
• W3096688043 cites W1543729365 @default.
• W3096688043 cites W1567572536 @default.
• W3096688043 cites W1971368546 @default.
• W3096688043 cites W1978909649 @default.
• W3096688043 cites W1978976757 @default.
• W3096688043 cites W2009750283 @default.
• W3096688043 cites W2010355346 @default.
• W3096688043 cites W2021583585 @default.
• W3096688043 cites W2023026925 @default.
• W3096688043 cites W2030460933 @default.
• W3096688043 cites W2032237444 @default.
• W3096688043 cites W2036498946 @default.
• W3096688043 cites W2042053670 @default.
• W3096688043 cites W2045207629 @default.
• W3096688043 cites W2046802480 @default.
• W3096688043 cites W2050995681 @default.
• W3096688043 cites W2055820698 @default.
• W3096688043 cites W2060650451 @default.
• W3096688043 cites W2076747850 @default.
• W3096688043 cites W2076781713 @default.
• W3096688043 cites W2081914959 @default.
• W3096688043 cites W2082448556 @default.
• W3096688043 cites W2092348954 @default.
• W3096688043 cites W2096024512 @default.
• W3096688043 cites W2098642477 @default.
• W3096688043 cites W2110504925 @default.
• W3096688043 cites W2114570899 @default.
• W3096688043 cites W2172674009 @default.
• W3096688043 cites W2436400166 @default.
• W3096688043 cites W2571369470 @default.
• W3096688043 cites W2595101650 @default.
• W3096688043 cites W2619818668 @default.
• W3096688043 cites W2799290037 @default.
• W3096688043 cites W2804067501 @default.
• W3096688043 cites W2850481338 @default.
• W3096688043 cites W2883753288 @default.
• W3096688043 cites W2886919003 @default.
• W3096688043 cites W2891692274 @default.
• W3096688043 cites W2899065184 @default.
• W3096688043 cites W2913581260 @default.
• W3096688043 cites W2936033672 @default.
• W3096688043 cites W2966063114 @default.
• W3096688043 cites W2976544843 @default.
• W3096688043 cites W2981757677 @default.
• W3096688043 cites W2982623967 @default.
• W3096688043 cites W2990111605 @default.
• W3096688043 cites W3008757165 @default.
• W3096688043 cites W3011933392 @default.
• W3096688043 cites W3015323280 @default.
• W3096688043 cites W3015551372 @default.
• W3096688043 cites W4230825363 @default.
• W3096688043 cites W4236577562 @default.
• W3096688043 cites W4239177710 @default.
• W3096688043 cites W4247077756 @default.
• W3096688043 cites W4251447053 @default.
• W3096688043 doi "https://doi.org/10.1167/iovs.61.13.3" @default.
• W3096688043 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7645203" @default.
• W3096688043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33137196" @default.
• W3096688043 hasPublicationYear "2020" @default.
• W3096688043 type Work @default.
• W3096688043 sameAs 3096688043 @default.
• W3096688043 citedByCount "10" @default.
• W3096688043 countsByYear W30966880432021 @default.
• W3096688043 countsByYear W30966880432022 @default.
• W3096688043 countsByYear W30966880432023 @default.
• W3096688043 crossrefType "journal-article" @default.
• W3096688043 hasAuthorship W3096688043A5009235404 @default.
• W3096688043 hasAuthorship W3096688043A5044459542 @default.
• W3096688043 hasAuthorship W3096688043A5080349207 @default.
• W3096688043 hasAuthorship W3096688043A5081262873 @default.
• W3096688043 hasBestOaLocation W30966880431 @default.
• W3096688043 hasConcept C105702510 @default.
• W3096688043 hasConcept C170493617 @default.
• W3096688043 hasConcept C185592680 @default.
• W3096688043 hasConcept C2777052854 @default.
• W3096688043 hasConcept C2777389121 @default.
• W3096688043 hasConcept C2780802079 @default.
• W3096688043 hasConcept C55493867 @default.
• W3096688043 hasConcept C86803240 @default.
• W3096688043 hasConcept C98274493 @default.
• W3096688043 hasConceptScore W3096688043C105702510 @default.
• W3096688043 hasConceptScore W3096688043C170493617 @default.
• W3096688043 hasConceptScore W3096688043C185592680 @default.
• W3096688043 hasConceptScore W3096688043C2777052854 @default.
• W3096688043 hasConceptScore W3096688043C2777389121 @default.
• W3096688043 hasConceptScore W3096688043C2780802079 @default.
• W3096688043 hasConceptScore W3096688043C55493867 @default.
• W3096688043 hasConceptScore W3096688043C86803240 @default.
• W3096688043 hasConceptScore W3096688043C98274493 @default.

• next