FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3096709738> ?p ?o ?g. }

• W3096709738 abstract "Efficacy for COVID-19 treatments can be enhanced significantly through targeting the nasopharynx, which has been shown to be the dominant preliminary infection site for SARS-CoV-2. Although intranasal drugs can be administered easily through drops or sprays, it is difficult to test whether current protocols will deliver the right amount of the drug to this location consistently. We are interested in developing an in silico prototyping tool to rapidly identify optimal parameters for intranasal delivery. In this study, we have applied computational fluid dynamics to simulate fluid flow through the nasal cavity and examined particle deposition for a drug formulation, mimicking different delivery methods. The nasal geometry models were derived using digitized and meshed computed tomography (CT) scans of human patients. Using the nasal geometries, we simulated two different airflows: a laminar model at 15 LPM (Liters/min) that simulated resting breathing rate and a Large Eddy Simulation (LES) model used to achieve a higher flow rate of 30 LPM. We were able to run particle tracking simulations for these two airflow schemes to test different drug properties such as particle size. The different injection methods used include surface injection which best replicates an inhaler-based release of particle droplets into the nostril and the cone injection method which best replicates a spray into the nostril. The results of the study suggest that the most optimal drug particle size for targeting the intranasal infection sites is around 6-14 microns." @default.
• W3096709738 created "2020-11-09" @default.
• W3096709738 creator A5003590065 @default.
• W3096709738 creator A5003610011 @default.
• W3096709738 creator A5035333687 @default.
• W3096709738 creator A5050864861 @default.
• W3096709738 creator A5056189696 @default.
• W3096709738 creator A5066868698 @default.
• W3096709738 creator A5070449379 @default.
• W3096709738 date "2020-10-30" @default.
• W3096709738 modified "2023-09-27" @default.
• W3096709738 title "Identifying the optimal parameters for sprayed and inhaled drug particulates for intranasal targeting of SARS-CoV-2 infection sites." @default.
• W3096709738 cites W1520378998 @default.
• W3096709738 cites W1969023905 @default.
• W3096709738 cites W2027832282 @default.
• W3096709738 cites W2155477672 @default.
• W3096709738 cites W2743687210 @default.
• W3096709738 cites W2963752946 @default.
• W3096709738 cites W3015571324 @default.
• W3096709738 cites W3020188044 @default.
• W3096709738 cites W3020534866 @default.
• W3096709738 cites W3037810750 @default.
• W3096709738 cites W3091385933 @default.
• W3096709738 cites W3093231971 @default.
• W3096709738 cites W3125942575 @default.
• W3096709738 cites W3203207581 @default.
• W3096709738 hasPublicationYear "2020" @default.
• W3096709738 type Work @default.
• W3096709738 sameAs 3096709738 @default.
• W3096709738 citedByCount "0" @default.
• W3096709738 crossrefType "posted-content" @default.
• W3096709738 hasAuthorship W3096709738A5003590065 @default.
• W3096709738 hasAuthorship W3096709738A5003610011 @default.
• W3096709738 hasAuthorship W3096709738A5035333687 @default.
• W3096709738 hasAuthorship W3096709738A5050864861 @default.
• W3096709738 hasAuthorship W3096709738A5056189696 @default.
• W3096709738 hasAuthorship W3096709738A5066868698 @default.
• W3096709738 hasAuthorship W3096709738A5070449379 @default.
• W3096709738 hasConcept C116067010 @default.
• W3096709738 hasConcept C121332964 @default.
• W3096709738 hasConcept C127413603 @default.
• W3096709738 hasConcept C136229726 @default.
• W3096709738 hasConcept C141071460 @default.
• W3096709738 hasConcept C147789679 @default.
• W3096709738 hasConcept C171250308 @default.
• W3096709738 hasConcept C185592680 @default.
• W3096709738 hasConcept C187530423 @default.
• W3096709738 hasConcept C18903297 @default.
• W3096709738 hasConcept C192562407 @default.
• W3096709738 hasConcept C196558001 @default.
• W3096709738 hasConcept C200457457 @default.
• W3096709738 hasConcept C203014093 @default.
• W3096709738 hasConcept C2776042228 @default.
• W3096709738 hasConcept C2777419714 @default.
• W3096709738 hasConcept C2778311950 @default.
• W3096709738 hasConcept C2778517922 @default.
• W3096709738 hasConcept C2778801703 @default.
• W3096709738 hasConcept C2779789940 @default.
• W3096709738 hasConcept C2779820397 @default.
• W3096709738 hasConcept C2780261241 @default.
• W3096709738 hasConcept C2961886 @default.
• W3096709738 hasConcept C57879066 @default.
• W3096709738 hasConcept C71924100 @default.
• W3096709738 hasConcept C78519656 @default.
• W3096709738 hasConcept C85663871 @default.
• W3096709738 hasConcept C86803240 @default.
• W3096709738 hasConcept C98274493 @default.
• W3096709738 hasConceptScore W3096709738C116067010 @default.
• W3096709738 hasConceptScore W3096709738C121332964 @default.
• W3096709738 hasConceptScore W3096709738C127413603 @default.
• W3096709738 hasConceptScore W3096709738C136229726 @default.
• W3096709738 hasConceptScore W3096709738C141071460 @default.
• W3096709738 hasConceptScore W3096709738C147789679 @default.
• W3096709738 hasConceptScore W3096709738C171250308 @default.
• W3096709738 hasConceptScore W3096709738C185592680 @default.
• W3096709738 hasConceptScore W3096709738C187530423 @default.
• W3096709738 hasConceptScore W3096709738C18903297 @default.
• W3096709738 hasConceptScore W3096709738C192562407 @default.
• W3096709738 hasConceptScore W3096709738C196558001 @default.
• W3096709738 hasConceptScore W3096709738C200457457 @default.
• W3096709738 hasConceptScore W3096709738C203014093 @default.
• W3096709738 hasConceptScore W3096709738C2776042228 @default.
• W3096709738 hasConceptScore W3096709738C2777419714 @default.
• W3096709738 hasConceptScore W3096709738C2778311950 @default.
• W3096709738 hasConceptScore W3096709738C2778517922 @default.
• W3096709738 hasConceptScore W3096709738C2778801703 @default.
• W3096709738 hasConceptScore W3096709738C2779789940 @default.
• W3096709738 hasConceptScore W3096709738C2779820397 @default.
• W3096709738 hasConceptScore W3096709738C2780261241 @default.
• W3096709738 hasConceptScore W3096709738C2961886 @default.
• W3096709738 hasConceptScore W3096709738C57879066 @default.
• W3096709738 hasConceptScore W3096709738C71924100 @default.
• W3096709738 hasConceptScore W3096709738C78519656 @default.
• W3096709738 hasConceptScore W3096709738C85663871 @default.
• W3096709738 hasConceptScore W3096709738C86803240 @default.
• W3096709738 hasConceptScore W3096709738C98274493 @default.
• W3096709738 hasLocation W30967097381 @default.
• W3096709738 hasOpenAccess W3096709738 @default.
• W3096709738 hasPrimaryLocation W30967097381 @default.
• W3096709738 isParatext "false" @default.

• next