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- W3096736124 abstract "Heme peroxidases oxidize a diverse array of substrates using hydrogen peroxide as the terminal oxidant. The catalytic cycle involves the transient formation of compound I and compound II, iconic ferryl intermediates that appear across a diverse group of heme enzymes, including cytochrome P450s, nitric oxide synthases and the terminal oxidases. This article is designed to cover the modern developments in the peroxidase field and is not intended as a comprehensive review. We will highlight a new generation of structural methods, including neutron diffraction and X-ray free electron lasers that avoid photoreduction of the iron center and allow the precise chemical nature of ferryl intermediates to be determined. The introduction of non-canonical axial heme ligands using an expanded genetic code has led to peroxidases with augmented properties and has allowed new structure-activity relationships to be conducted directly in enzyme active sites, revealing new insights into the factors governing ferryl heme reactivity. Finally, advances in protein design and engineering have led to the development of highly efficient de novo heme peroxidases with interesting catalytic properties. We anticipate that the emerging strategies for metalloenzyme design, engineering and characterization outlined in this chapter will continue to play key roles in driving our understanding of bioinorganic chemistry." @default.
- W3096736124 created "2020-11-09" @default.
- W3096736124 creator A5004151092 @default.
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- W3096736124 creator A5074254221 @default.
- W3096736124 date "2021-01-01" @default.
- W3096736124 modified "2023-09-27" @default.
- W3096736124 title "Recent Advances in Understanding, Enhancing and Creating Heme Peroxidases" @default.
- W3096736124 cites W1504677789 @default.
- W3096736124 cites W1505024032 @default.
- W3096736124 cites W1530595315 @default.
- W3096736124 cites W1596187806 @default.
- W3096736124 cites W1968547522 @default.
- W3096736124 cites W1968688891 @default.
- W3096736124 cites W1969318838 @default.
- W3096736124 cites W1970121537 @default.
- W3096736124 cites W1970836398 @default.
- W3096736124 cites W1976916999 @default.
- W3096736124 cites W1977515956 @default.
- W3096736124 cites W1980372703 @default.
- W3096736124 cites W1980419942 @default.
- W3096736124 cites W1991610652 @default.
- W3096736124 cites W1993579387 @default.
- W3096736124 cites W1995002017 @default.
- W3096736124 cites W2001265759 @default.
- W3096736124 cites W2003881693 @default.
- W3096736124 cites W2005043252 @default.
- W3096736124 cites W2007291214 @default.
- W3096736124 cites W2008866677 @default.
- W3096736124 cites W2013547144 @default.
- W3096736124 cites W2016289343 @default.
- W3096736124 cites W2016943233 @default.
- W3096736124 cites W2019137326 @default.
- W3096736124 cites W2020351667 @default.
- W3096736124 cites W2039733535 @default.
- W3096736124 cites W2039822074 @default.
- W3096736124 cites W2044705084 @default.
- W3096736124 cites W2044795432 @default.
- W3096736124 cites W2049126415 @default.
- W3096736124 cites W2050371810 @default.
- W3096736124 cites W2061678146 @default.
- W3096736124 cites W2064447953 @default.
- W3096736124 cites W2064576403 @default.
- W3096736124 cites W2067218778 @default.
- W3096736124 cites W2072679497 @default.
- W3096736124 cites W2073239636 @default.
- W3096736124 cites W2077445215 @default.
- W3096736124 cites W2080685866 @default.
- W3096736124 cites W2083744110 @default.
- W3096736124 cites W2095027417 @default.
- W3096736124 cites W2102028493 @default.
- W3096736124 cites W2107277439 @default.
- W3096736124 cites W2108947564 @default.
- W3096736124 cites W2109960907 @default.
- W3096736124 cites W2110385738 @default.
- W3096736124 cites W2110810524 @default.
- W3096736124 cites W2121967553 @default.
- W3096736124 cites W2127870464 @default.
- W3096736124 cites W2136750089 @default.
- W3096736124 cites W2138393107 @default.
- W3096736124 cites W2139094273 @default.
- W3096736124 cites W2153563207 @default.
- W3096736124 cites W2210464517 @default.
- W3096736124 cites W2252581239 @default.
- W3096736124 cites W2291638706 @default.
- W3096736124 cites W2317873538 @default.
- W3096736124 cites W2465674018 @default.
- W3096736124 cites W2511472401 @default.
- W3096736124 cites W2559265301 @default.
- W3096736124 cites W2608503545 @default.
- W3096736124 cites W2618711414 @default.
- W3096736124 cites W2747381152 @default.
- W3096736124 cites W2778341989 @default.
- W3096736124 cites W2783280297 @default.
- W3096736124 cites W2784128645 @default.
- W3096736124 cites W2801981469 @default.
- W3096736124 cites W2808113866 @default.
- W3096736124 cites W2808271885 @default.
- W3096736124 cites W2888383240 @default.
- W3096736124 cites W2891571079 @default.
- W3096736124 cites W2891999158 @default.
- W3096736124 cites W2895441861 @default.
- W3096736124 cites W2898459031 @default.
- W3096736124 cites W2898795971 @default.
- W3096736124 cites W2903339471 @default.
- W3096736124 cites W2944972069 @default.
- W3096736124 cites W2949168575 @default.
- W3096736124 cites W2961679963 @default.
- W3096736124 cites W2997328557 @default.
- W3096736124 cites W3004224687 @default.
- W3096736124 cites W3009062492 @default.
- W3096736124 cites W3021991233 @default.
- W3096736124 cites W4251377287 @default.
- W3096736124 doi "https://doi.org/10.1016/b978-0-08-102688-5.00021-0" @default.
- W3096736124 hasPublicationYear "2021" @default.
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