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- W3096755862 abstract "Abstract This research utilized the systematic biological and proteomics strategies to explore the regulatory mechanism of Danshen Yin Modified (DSYM) on atherosclerosis (AS) biological network. The traditional Chinese medicine database and HPLC was used to find the active compounds of DSYM, Pharmmapper database was used to predict potential targets, and OMIM database and GeneCards database were used to collect AS targets. String database was utilized to obtain the other protein of proteomics proteins and the protein‐protein interaction (PPI) data of DSYM targets, AS genes, proteomics proteins and other proteins. The Cytoscape 3.7.1 software was utilized to construct and analyse the network. The DAVID database is used to discover the biological processes and signalling pathways that these proteins aggregate. Finally, animal experiments and proteomics analysis were used to further verify the prediction results. The results showed that 140 active compounds, 405 DSYM targets and 590 AS genes were obtained, and 51 differentially expressed proteins were identified in the DSYM‐treated ApoE‐/‐ mouse AS model. A total of 4 major networks and a number of their derivative networks were constructed and analysed. The prediction results showed that DSYM can regulate AS‐related biological processes and signalling pathways. Animal experiments have also shown that DSYM has a therapeutic effect on ApoE‐/‐mouse AS model ( P < .05). Therefore, this study proposed a new method based on systems biology, proteomics, and experimental pharmacology, and analysed the pharmacological mechanism of DSYM. DSYM may achieve therapeutic effects by regulating AS‐related signalling pathways and biological processes found in this research." @default.
- W3096755862 created "2020-11-09" @default.
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- W3096755862 date "2020-11-02" @default.
- W3096755862 modified "2023-10-05" @default.
- W3096755862 title "Integrating systematic biological and proteomics strategies to explore the pharmacological mechanism of danshen yin modified on atherosclerosis" @default.
- W3096755862 cites W1210128517 @default.
- W3096755862 cites W1252536816 @default.
- W3096755862 cites W1834266271 @default.
- W3096755862 cites W1949072443 @default.
- W3096755862 cites W1976500720 @default.
- W3096755862 cites W1981784337 @default.
- W3096755862 cites W1986019364 @default.
- W3096755862 cites W1995591143 @default.
- W3096755862 cites W2022300016 @default.
- W3096755862 cites W2028385130 @default.
- W3096755862 cites W2028574905 @default.
- W3096755862 cites W2033153389 @default.
- W3096755862 cites W2045932944 @default.
- W3096755862 cites W2055724461 @default.
- W3096755862 cites W2058192235 @default.
- W3096755862 cites W2062254269 @default.
- W3096755862 cites W2070603512 @default.
- W3096755862 cites W2073452619 @default.
- W3096755862 cites W2075381648 @default.
- W3096755862 cites W2076745667 @default.
- W3096755862 cites W2094568831 @default.
- W3096755862 cites W2096173332 @default.
- W3096755862 cites W2098082628 @default.
- W3096755862 cites W2101128162 @default.
- W3096755862 cites W2107611361 @default.
- W3096755862 cites W2117677020 @default.
- W3096755862 cites W2118204146 @default.
- W3096755862 cites W2119252289 @default.
- W3096755862 cites W2119412782 @default.
- W3096755862 cites W2124679671 @default.
- W3096755862 cites W2124860998 @default.
- W3096755862 cites W2135881373 @default.
- W3096755862 cites W2136850043 @default.
- W3096755862 cites W2137480174 @default.
- W3096755862 cites W2144114662 @default.
- W3096755862 cites W2158217645 @default.
- W3096755862 cites W2163821555 @default.
- W3096755862 cites W2165472969 @default.
- W3096755862 cites W2276012049 @default.
- W3096755862 cites W2317441279 @default.
- W3096755862 cites W2324472330 @default.
- W3096755862 cites W2327297222 @default.
- W3096755862 cites W2332051724 @default.
- W3096755862 cites W2336173165 @default.
- W3096755862 cites W2347803572 @default.
- W3096755862 cites W244202047 @default.
- W3096755862 cites W2474747771 @default.
- W3096755862 cites W2480486349 @default.
- W3096755862 cites W2504255207 @default.
- W3096755862 cites W2533066341 @default.
- W3096755862 cites W2582063619 @default.
- W3096755862 cites W2611425558 @default.
- W3096755862 cites W2616120362 @default.
- W3096755862 cites W2748917495 @default.
- W3096755862 cites W2753823906 @default.
- W3096755862 cites W2768194822 @default.
- W3096755862 cites W2772091244 @default.
- W3096755862 cites W2789377753 @default.
- W3096755862 cites W2789548022 @default.
- W3096755862 cites W2793675081 @default.
- W3096755862 cites W2796403010 @default.
- W3096755862 cites W2799619230 @default.
- W3096755862 cites W2806741586 @default.
- W3096755862 cites W2810856837 @default.
- W3096755862 cites W2897389369 @default.
- W3096755862 cites W2903061874 @default.
- W3096755862 cites W2911491594 @default.
- W3096755862 cites W2942368772 @default.
- W3096755862 cites W2949806030 @default.
- W3096755862 cites W2951495804 @default.
- W3096755862 cites W2951883591 @default.
- W3096755862 cites W2954694261 @default.
- W3096755862 cites W2955108563 @default.
- W3096755862 cites W2955387872 @default.
- W3096755862 cites W2964952983 @default.
- W3096755862 cites W2970870737 @default.
- W3096755862 cites W2984699575 @default.
- W3096755862 cites W2994384948 @default.
- W3096755862 cites W3096755862 @default.
- W3096755862 cites W3152191068 @default.
- W3096755862 cites W4240019765 @default.
- W3096755862 cites W4252019796 @default.