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- W3096756076 abstract "Abstract Centromeres are defined by the location of Centromeric Histone H3 (CENP-A/CENH3) which interacts with DNA to define the locations and sizes of functional centromeres. An analysis of 26 maize genomes including 110 fully assembled centromeric regions revealed positive relationships between centromere size and genome size. These effects are independent of variation in the amounts of the major centromeric satellite sequence CentC. We also backcrossed known centromeres into two different lines with larger genomes and observed consistent increases in functional centromere sizes for multiple centromeres. Although changes in centromere size involve changes in bound CENH3, we could not mimic the effect by overexpressing CENH3 by threefold. Literature from other fields demonstrate that changes in genome size affect protein levels, organelle size and cell size. Our data demonstrate that centromere size is among these scalable features, and that multiple limiting factors together contribute to a stable centromere size equilibrium." @default.
- W3096756076 created "2020-11-09" @default.
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- W3096756076 date "2020-11-05" @default.
- W3096756076 modified "2023-09-27" @default.
- W3096756076 title "Maize centromeric chromatin scales with changes in genome size" @default.
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- W3096756076 doi "https://doi.org/10.1101/2020.11.05.370262" @default.
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