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- W3096756482 endingPage "309" @default.
- W3096756482 startingPage "296" @default.
- W3096756482 abstract "Mesenchymal stem cells (MSCs), multipotent stromal cells, have attracted extensive attention in the field of regenerative medicine and cell therapy due to the capacity of self-renewal, multilineage differentiation, and immune regulation. MSCs have different cellular effects in different diseases, and even have markedly different curative effects with different tissue sources, indicating the plasticity of MSCs. The phenotypes, secreted factors, and proliferative, migratory, differentiating, and immunomodulatory effects of MSCs depend on certain mediators present in their microenvironment. Understanding microenvironmental factors and their internal mechanisms in MSC responses may help in subsequent prediction and improvement of clinical benefits. This review highlighted the recent advances in MSC plasticity in the physiological and pathological microenvironment and multiple microenvironmental factors regulating MSC plasticity. It also highlighted some progress in the underlying molecular mechanisms of MSC remodeling in the microenvironment. It might provide references for the improvement in vitro culture of MSCs, clinical application, and in vivo induction." @default.
- W3096756482 created "2020-11-09" @default.
- W3096756482 creator A5017692375 @default.
- W3096756482 creator A5027937292 @default.
- W3096756482 creator A5048874956 @default.
- W3096756482 creator A5078047179 @default.
- W3096756482 date "2022-03-01" @default.
- W3096756482 modified "2023-10-12" @default.
- W3096756482 title "Characteristics and regulation of mesenchymal stem cell plasticity by the microenvironment — specific factors involved in the regulation of MSC plasticity" @default.
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