Matches in SemOpenAlex for { <https://semopenalex.org/work/W3096758810> ?p ?o ?g. }
- W3096758810 endingPage "72" @default.
- W3096758810 startingPage "62" @default.
- W3096758810 abstract "Multi-system involvement and rapid clinical deterioration are hallmarks of coronavirus disease 2019 (COVID-19) related mortality. The unique clinical phenomena in severe COVID-19 can be perplexing, and they include disproportionately severe hypoxemia relative to lung alveolar-parenchymal pathology and rapid clinical deterioration, with poor response to O2 supplementation, despite preserved lung mechanics. Factors such as microvascular injury, thromboembolism, pulmonary hypertension, and alteration in hemoglobin structure and function could play important roles. Overwhelming immune response associated with cytokine storms could activate reactive oxygen species (ROS), which may result in consumption of nitric oxide (NO), a critical vasodilation regulator. In other inflammatory infections, activated neutrophils are known to release myeloperoxidase (MPO) in a natural immune response, which contributes to production of hypochlorous acid (HOCl). However, during overwhelming inflammation, HOCl competes with O2 at heme binding sites, decreasing O2 saturation. Moreover, HOCl contributes to several oxidative reactions, including hemoglobin-heme iron oxidation, heme destruction, and subsequent release of free iron, which mediates toxic tissue injury through additional generation of ROS and NO consumption. Connecting these reactions in a multi-hit model can explain generalized tissue damage, vasoconstriction, severe hypoxia, and precipitous clinical deterioration in critically ill COVID-19 patients. Understanding these mechanisms is critical to develop therapeutic strategies to combat COVID-19." @default.
- W3096758810 created "2020-11-09" @default.
- W3096758810 creator A5013450877 @default.
- W3096758810 creator A5054869923 @default.
- W3096758810 creator A5077074927 @default.
- W3096758810 date "2021-01-01" @default.
- W3096758810 modified "2023-10-03" @default.
- W3096758810 title "A Multiple-Hit Hypothesis Involving Reactive Oxygen Species and Myeloperoxidase Explains Clinical Deterioration and Fatality in COVID-19" @default.
- W3096758810 cites W1566799753 @default.
- W3096758810 cites W1586165122 @default.
- W3096758810 cites W1626570152 @default.
- W3096758810 cites W1632699915 @default.
- W3096758810 cites W170022325 @default.
- W3096758810 cites W1769808070 @default.
- W3096758810 cites W1838909952 @default.
- W3096758810 cites W1925799544 @default.
- W3096758810 cites W1940436875 @default.
- W3096758810 cites W1968754725 @default.
- W3096758810 cites W1968941213 @default.
- W3096758810 cites W1970096539 @default.
- W3096758810 cites W1976599392 @default.
- W3096758810 cites W1984328389 @default.
- W3096758810 cites W2003749942 @default.
- W3096758810 cites W2005132438 @default.
- W3096758810 cites W2006754144 @default.
- W3096758810 cites W2012018808 @default.
- W3096758810 cites W2018992923 @default.
- W3096758810 cites W2022734495 @default.
- W3096758810 cites W2023099428 @default.
- W3096758810 cites W2023695511 @default.
- W3096758810 cites W2035961359 @default.
- W3096758810 cites W2038561084 @default.
- W3096758810 cites W2044474988 @default.
- W3096758810 cites W2048086807 @default.
- W3096758810 cites W2048554453 @default.
- W3096758810 cites W2050808395 @default.
- W3096758810 cites W2051908396 @default.
- W3096758810 cites W2064660491 @default.
- W3096758810 cites W2066248940 @default.
- W3096758810 cites W2080983244 @default.
- W3096758810 cites W2082433263 @default.
- W3096758810 cites W2083558299 @default.
- W3096758810 cites W2087141403 @default.
- W3096758810 cites W2091924757 @default.
- W3096758810 cites W2092105586 @default.
- W3096758810 cites W2092865574 @default.
- W3096758810 cites W2118209298 @default.
- W3096758810 cites W2119501943 @default.
- W3096758810 cites W2126657029 @default.
- W3096758810 cites W2132663598 @default.
- W3096758810 cites W2132826785 @default.
- W3096758810 cites W2136443108 @default.
- W3096758810 cites W2147173298 @default.
- W3096758810 cites W2151417342 @default.
- W3096758810 cites W2156273941 @default.
- W3096758810 cites W2162853795 @default.
- W3096758810 cites W2162986958 @default.
- W3096758810 cites W2166559444 @default.
- W3096758810 cites W2167872299 @default.
- W3096758810 cites W2295770513 @default.
- W3096758810 cites W2328568398 @default.
- W3096758810 cites W2342612813 @default.
- W3096758810 cites W2470646526 @default.
- W3096758810 cites W2518642608 @default.
- W3096758810 cites W2738307679 @default.
- W3096758810 cites W2747004888 @default.
- W3096758810 cites W2765145472 @default.
- W3096758810 cites W2800988230 @default.
- W3096758810 cites W2883745760 @default.
- W3096758810 cites W2948576639 @default.
- W3096758810 cites W2949433873 @default.
- W3096758810 cites W2996274635 @default.
- W3096758810 cites W3001118548 @default.
- W3096758810 cites W3001465255 @default.
- W3096758810 cites W3004318991 @default.
- W3096758810 cites W3006252254 @default.
- W3096758810 cites W3006645647 @default.
- W3096758810 cites W3007940623 @default.
- W3096758810 cites W3008090866 @default.
- W3096758810 cites W3008461878 @default.
- W3096758810 cites W3008827533 @default.
- W3096758810 cites W3009314935 @default.
- W3096758810 cites W3009582878 @default.
- W3096758810 cites W3009859788 @default.
- W3096758810 cites W3009885589 @default.
- W3096758810 cites W3009976289 @default.
- W3096758810 cites W3010637630 @default.
- W3096758810 cites W3011152298 @default.
- W3096758810 cites W3012253443 @default.
- W3096758810 cites W3012721127 @default.
- W3096758810 cites W3012747666 @default.
- W3096758810 cites W3012849736 @default.
- W3096758810 cites W3013013063 @default.
- W3096758810 cites W3013180764 @default.
- W3096758810 cites W3013270768 @default.
- W3096758810 cites W3013334176 @default.
- W3096758810 cites W3013488343 @default.
- W3096758810 cites W3013671288 @default.