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• W3096764372 abstract "The SARS-CoV-2 immune response in human milk has not yet been examined, although protecting infants and young children from COVID-19 is critical for limiting community transmission and preventing serious illness and death. Here, milk samples from eight COVID-19-recovered and seven COVID-19-suspected donors were tested for antibody (Ab) binding to the SARS-CoV-2 Spike protein. All samples exhibited significant specific IgA reactivity to the full Spike, whereas 80% exhibited significant IgA and secretory (s)Ab binding to the Receptor-Binding Domain (RBD). Additionally, 67% samples exhibited IgG and/or IgM binding to RBD. IgA and sAb titers were highly correlated, indicating most IgA to be sIgA. Overall, these data indicate that a robust sIgA-dominant SARS-CoV-2 Ab response in human milk after infection should be expected in a significant majority of individuals. Further research is highly warranted to determine Ab functionality and the potential for exploiting extracted milk sIgA for therapeutic use." @default.
• W3096764372 created "2020-11-09" @default.
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• W3096764372 date "2020-11-01" @default.
• W3096764372 modified "2023-10-11" @default.
• W3096764372 title "Robust and Specific Secretory IgA Against SARS-CoV-2 Detected in Human Milk" @default.
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• W3096764372 doi "https://doi.org/10.1016/j.isci.2020.101735" @default.
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