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• W3096768390 abstract "The auditory system relies on temporal precise information transfer, requiring an interplay of synchronously activated inputs and rapid postsynaptic integration. During late postnatal developmental synaptic, biophysical, and morphological features change to enable matured auditory neurons to perform their appropriate function. How the number of minimal required input fibers and the relevant EPSC time course integrated for action potential generation changes during late postnatal development is unclear. To answer these questions we used in vitro electrophysiology in auditory brainstem structures from pre-hearing onset and mature Mongolian gerbils of either sex. Synaptic and biophysical parameters changed distinctively during development in the medial nucleus of the trapezoid body (MNTB), the medial superior olive (MSO), and the ventral and dorsal nucleus of the lateral lemniscus (VNLL and DNLL). Despite a reduction in input resistance in most cell types, all required fewer inputs in the mature stage to drive action potentials. Moreover, the EPSC decay time constant is a good predictor of the EPSC time used for action potential generation in all nuclei but the VNLL. Only in MSO neurons, the full EPSC time course is integrated by the neuron’s resistive element, while otherwise the relevant EPSC time matches only 5-10 % of the membrane time constant, indicating its dominant role for membrane charging. We conclude, that distinct developmental programs lead to a general increase in temporal precision and integration accuracy matched to the information relaying properties of auditory nuclei." @default.
• W3096768390 created "2020-11-09" @default.
• W3096768390 creator A5007937870 @default.
• W3096768390 creator A5065045607 @default.
• W3096768390 creator A5067968306 @default.
• W3096768390 date "2020-11-05" @default.
• W3096768390 modified "2023-10-11" @default.
• W3096768390 title "Minimal Number of Required Inputs for Temporally Precise Action Potential Generation in Auditory Brainstem Nuclei" @default.
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• W3096768390 doi "https://doi.org/10.3389/fncel.2020.592213" @default.
• W3096768390 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7674839" @default.
• W3096768390 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33250717" @default.
• W3096768390 hasPublicationYear "2020" @default.
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