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- W3096804594 endingPage "5144" @default.
- W3096804594 startingPage "5144" @default.
- W3096804594 abstract "Cancer is one of the highest prevalent diseases in humans. The chances of surviving cancer and its prognosis are very dependent on the affected tissue, body location, and stage at which the disease is diagnosed. Researchers and pharmaceutical companies worldwide are pursuing many attempts to look for compounds to treat this malignancy. Most of the current strategies to fight cancer implicate the use of compounds acting on DNA damage checkpoints, non-receptor tyrosine kinases activities, regulators of the hedgehog signaling pathways, and metabolic adaptations placed in cancer. In the last decade, the finding of a lipid peroxidation increase linked to 15-lipoxygenases isoform 1 (15-LOX-1) activity stimulation has been found in specific successful treatments against cancer. This discovery contrasts with the production of other lipid oxidation signatures generated by stimulation of other lipoxygenases such as 5-LOX and 12-LOX, and cyclooxygenase (COX-2) activities, which have been suggested as cancer biomarkers and which inhibitors present anti-tumoral and antiproliferative activities. These findings support the previously proposed role of lipid hydroperoxides and their metabolites as cancer cell mediators. Depletion or promotion of lipid peroxidation is generally related to a specific production source associated with a cancer stage or tissue in which cancer originates. This review highlights the potential therapeutical use of chemical derivatives to stimulate or block specific cellular routes to generate lipid hydroperoxides to treat this disease." @default.
- W3096804594 created "2020-11-09" @default.
- W3096804594 creator A5023331266 @default.
- W3096804594 creator A5055038712 @default.
- W3096804594 creator A5065432787 @default.
- W3096804594 creator A5082521080 @default.
- W3096804594 date "2020-11-05" @default.
- W3096804594 modified "2023-10-18" @default.
- W3096804594 title "Targeting Lipid Peroxidation for Cancer Treatment" @default.
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