FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3096853504> ?p ?o ?g. }

• W3096853504 endingPage "642" @default.
• W3096853504 startingPage "636" @default.
• W3096853504 abstract "The free-living flatworm Macrostomum mirumnovem is a neopolyploid species whose genome underwent a recent Whole Genome Duplication (WGD). In the result of chromosome fusions of the ancient haploid chromosome set, large metacentric chromosomes were formed. In addition to three pairs of small metacentrics, the current karyotype of M. mirumnovem contains two pairs of large metacentric chromosomes, MMI1 and MMI2. The generation of microdissected DNA libraries enriched for DNA repeats followed by DNA probe preparation and fluorescent in situ hybridization (FISH) were performed. The DNA probes obtained marked chromosome regions enriched for different DNA repeats in the M. mirumnovem chromosomes. The size and localization of these regions varied in different copies of large chromosomes. They varied even in homologous chromosomes, suggesting their divergence due to genome re-diploidization after a WGD. Besides the newly formed chromosome regions enriched for DNA repeats, B chromosomes were found in the karyotypes of the studied specimens of M. mirumnovem. These B chromosomes varied in size and morphology. FISH with microdissected DNA probes revealed that some Bs had a distinct DNA content. FISH could paint differently B chromosomes in different worms and even in the same sample. B chromosomes could carry a bright specific fluorescent signal or could show no fluorescent signal at all. In latter cases, the specific FISH signal could be absent even in the pericentromeric region of the B chromosome. Possible mechanisms of B chromosome formation and their further evolution are discussed. The results obtained indicate an important role that repetitive DNAs play in genome re-diploidization initiating a rapid differentiation of large chromosome copies. Taking together, karyotype peculiarities (a high level of intraspecific karyotypic diversity associated with chromosome number variation, structural chromosomal rearrangements, and the formation of new regions enriched for DNA repeats) and some phenotypic features of M. mirumnovem (small body size, short lifecycle, easy maintenance in the laboratory) make this species a perspective model in the studies of genomic and karyotypic evolution in species passed through a recent WGD event." @default.
• W3096853504 created "2020-11-09" @default.
• W3096853504 creator A5030261146 @default.
• W3096853504 creator A5054930045 @default.
• W3096853504 date "2020-10-28" @default.
• W3096853504 modified "2023-10-03" @default.
• W3096853504 title "Regions enriched for DNA repeats in chromosomes of Macrostomum mirumnovem, a species with a recent Whole Genome Duplication" @default.
• W3096853504 cites W1983959798 @default.
• W3096853504 cites W2062237303 @default.
• W3096853504 cites W2065636600 @default.
• W3096853504 cites W2116876658 @default.
• W3096853504 cites W2151956719 @default.
• W3096853504 cites W2172119655 @default.
• W3096853504 cites W2489859759 @default.
• W3096853504 cites W2788154793 @default.
• W3096853504 cites W2803643362 @default.
• W3096853504 cites W2994837283 @default.
• W3096853504 doi "https://doi.org/10.18699/vj20.657" @default.
• W3096853504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7716556" @default.
• W3096853504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33659849" @default.
• W3096853504 hasPublicationYear "2020" @default.
• W3096853504 type Work @default.
• W3096853504 sameAs 3096853504 @default.
• W3096853504 citedByCount "1" @default.
• W3096853504 countsByYear W30968535042021 @default.
• W3096853504 crossrefType "journal-article" @default.
• W3096853504 hasAuthorship W3096853504A5030261146 @default.
• W3096853504 hasAuthorship W3096853504A5054930045 @default.
• W3096853504 hasBestOaLocation W30968535041 @default.
• W3096853504 hasConcept C104317684 @default.
• W3096853504 hasConcept C141231307 @default.
• W3096853504 hasConcept C143191323 @default.
• W3096853504 hasConcept C169802333 @default.
• W3096853504 hasConcept C2777542201 @default.
• W3096853504 hasConcept C30481170 @default.
• W3096853504 hasConcept C53226629 @default.
• W3096853504 hasConcept C54355233 @default.
• W3096853504 hasConcept C54815482 @default.
• W3096853504 hasConcept C552990157 @default.
• W3096853504 hasConcept C64894306 @default.
• W3096853504 hasConcept C86803240 @default.
• W3096853504 hasConceptScore W3096853504C104317684 @default.
• W3096853504 hasConceptScore W3096853504C141231307 @default.
• W3096853504 hasConceptScore W3096853504C143191323 @default.
• W3096853504 hasConceptScore W3096853504C169802333 @default.
• W3096853504 hasConceptScore W3096853504C2777542201 @default.
• W3096853504 hasConceptScore W3096853504C30481170 @default.
• W3096853504 hasConceptScore W3096853504C53226629 @default.
• W3096853504 hasConceptScore W3096853504C54355233 @default.
• W3096853504 hasConceptScore W3096853504C54815482 @default.
• W3096853504 hasConceptScore W3096853504C552990157 @default.
• W3096853504 hasConceptScore W3096853504C64894306 @default.
• W3096853504 hasConceptScore W3096853504C86803240 @default.
• W3096853504 hasIssue "6" @default.
• W3096853504 hasLocation W30968535041 @default.
• W3096853504 hasLocation W30968535042 @default.
• W3096853504 hasLocation W30968535043 @default.
• W3096853504 hasOpenAccess W3096853504 @default.
• W3096853504 hasPrimaryLocation W30968535041 @default.
• W3096853504 hasRelatedWork W1970446973 @default.
• W3096853504 hasRelatedWork W2010761654 @default.
• W3096853504 hasRelatedWork W2020646582 @default.
• W3096853504 hasRelatedWork W2028183827 @default.
• W3096853504 hasRelatedWork W2029806801 @default.
• W3096853504 hasRelatedWork W2740861913 @default.
• W3096853504 hasRelatedWork W2900071468 @default.
• W3096853504 hasRelatedWork W3030203460 @default.
• W3096853504 hasRelatedWork W3096853504 @default.
• W3096853504 hasRelatedWork W3208409679 @default.
• W3096853504 hasVolume "24" @default.
• W3096853504 isParatext "false" @default.
• W3096853504 isRetracted "false" @default.
• W3096853504 magId "3096853504" @default.
• W3096853504 workType "article" @default.