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- W3096870836 abstract "Peroxynitrite, one of the well-known reactive nitrogen species (RNS), which is considered to be an important oxidant. Besides, peroxynitrite plays an important role in the broad spectrum of biological processes, and it is also a vital participant in the emergence of cancer. To this end, the fluorescent probe PN-1 was rationally synthesized, which contains a coumarin-fused coumarin dye and borates as the specific recognition group. Probe PN-1 exhibits several obvious performances, for instance, high specificity, excellent sensitivity, and it could promptly respond toward ONOO−. Using this simple fluorescent probe, we achieved the imaging of endogenous and exogenous ONOO− fluctuations in living cells and zebrafish. Moreover, PN-1 has efficiently differentiated cancerous cells from normal cells owing to image their different native ONOO− levels, these results indicated that PN-1 is expected to be an analytical tool, for researching ONOO− related cancer biology and studying the related effect of ONOO− in food." @default.
- W3096870836 created "2020-11-09" @default.
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- W3096870836 date "2021-02-01" @default.
- W3096870836 modified "2023-10-11" @default.
- W3096870836 title "A novel ultrasensitive peroxynitrite-specific fluorescent probe and its bioimaging applications in living systems" @default.
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- W3096870836 doi "https://doi.org/10.1016/j.dyepig.2020.108982" @default.
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