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• W3096874531 startingPage "16085" @default.
• W3096874531 abstract "Inorganic ion metabolism plays significant roles in various life processes including signal transduction, substance exchange, and cellular constructions. Regulation and monitoring of ion metabolism offer great promise to modulate biological activities and provide insights into related mechanisms. Here, a synergistic nanodepot based on a bioactive core–shell CaF2 upconversion nanostructure that integrates multiple mineral ions for metabolic regulation was built for the acceleration and monitoring of the biomineralization process. Multiple mineral ions released from the nanodepots can accelerate the growth of inorganic crystals and enhance the production of organic matrixes, synergistically facilitating the regeneration of bone defects in vivo. During the process, such a nanodepot can be constructed to specifically recognize osteoblasts for the monitoring of biomineralization. This nanoprobe represents an efficient strategy to promote and monitor biomineralization-related metabolic activities with applications in fundamental research, disease diagnosis, and regenerative medicine." @default.
• W3096874531 created "2020-11-09" @default.
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• W3096874531 date "2020-11-05" @default.
• W3096874531 modified "2023-10-15" @default.
• W3096874531 title "Bioactive Core–Shell CaF₂ Upconversion Nanostructure for Promotion and Visualization of Engineered Bone Reconstruction" @default.
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• W3096874531 doi "https://doi.org/10.1021/acsnano.0c08013" @default.
• W3096874531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33151671" @default.
• W3096874531 hasPublicationYear "2020" @default.
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