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- W3096883503 abstract "Abstract Acquired resistance to temozolomide (TMZ) is a major obstacle in glioblastoma treatment. MGMT, a DNA repair protein, and the methylation at its gene promoter, plays an important role in TMZ resistance. However, some evidences have suggested a MGMT-independent mechanisms underlying TMZ resistance. Here, we used MGMT enhancer as a model and discovered that its deletion in glioma cells of low MGMT expression induced increased sensitivity to temozolomide. Analysis of a combination of RNA-seq and Capture Hi-C further suggested multiple long-range target genes regulated by the MGMT enhancer and that interactions may play important roles in glioma cell sensitivity to TMZ. This study reveals a novel mechanism of regulation of TMZ sensitivity in glioma cells." @default.
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- W3096883503 date "2020-11-04" @default.
- W3096883503 modified "2023-10-16" @default.
- W3096883503 title "Long-range gene regulation network of the MGMT enhancer in modulating glioma cell sensitivity to temozolomide" @default.
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- W3096883503 doi "https://doi.org/10.1101/2020.11.03.367268" @default.
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