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• W3096888251 endingPage "8018" @default.
• W3096888251 startingPage "8018" @default.
• W3096888251 abstract "The Wnt pathway is an integral cell-to-cell signaling hub which regulates crucial development processes and maintenance of tissue homeostasis by coordinating cell proliferation, differentiation, cell polarity, cell movement, and stem cell renewal. When dysregulated, it is associated with various developmental diseases, fibrosis, and tumorigenesis. We now better appreciate the complexity and crosstalk of the Wnt pathway with other signaling cascades. Emerging roles of the Wnt signaling in the cancer stem cell niche and drug resistance have led to development of therapeutics specifically targeting various Wnt components, with some agents currently in clinical trials. This review highlights historical and recent findings on key mediators of Wnt signaling and how they impact antitumor immunity and maintenance of cancer stem cells. This review also examines current therapeutics being developed that modulate Wnt signaling in cancer and discusses potential shortcomings associated with available therapeutics." @default.
• W3096888251 created "2020-11-09" @default.
• W3096888251 creator A5043713444 @default.
• W3096888251 creator A5047930038 @default.
• W3096888251 date "2020-10-28" @default.
• W3096888251 modified "2023-10-15" @default.
• W3096888251 title "Wnt Pathway: An Integral Hub for Developmental and Oncogenic Signaling Networks" @default.
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