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- W3096948603 abstract "Significance The role of the selectivity filter in controlling potassium channel activity is different for different channels, despite identical sequences and structures. While KcsA and voltage-gated channels experience C-type inactivation by collapsing their selectivity filters under reduced potassium concentration, the mechanism by which the MthK channel regulates gating at the filter is unclear. Unlike the KcsA selectivity filter that experiences a uniform titration of its ion binding sites, leading to collapse, high-resolution X-ray structures of the pore-only MthK channel reveal that only the central S2 site loses its ion at low concentrations, insufficient for a conformational change. The selectivity filters of MthK and KcsA differ in their ion affinities due to interactions behind the filter, determining their inactivation phenotypes." @default.
- W3096948603 created "2020-11-09" @default.
- W3096948603 creator A5004625895 @default.
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- W3096948603 date "2020-11-05" @default.
- W3096948603 modified "2023-10-01" @default.
- W3096948603 title "Selectivity filter ion binding affinity determines inactivation in a potassium channel" @default.
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- W3096948603 doi "https://doi.org/10.1073/pnas.2009624117" @default.
- W3096948603 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7703589" @default.
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