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• W3096988168 abstract "Abstract Previously, we have reported that 3-hydroxypropionate (3-HP) tolerance in Escherichia coli W is improved by deletion of yieP , a less-studied transcription factor. Here, through systems analyses along with physiological and functional studies, we suggest that the yieP deletion improves 3-HP tolerance by upregulation of yohJK , encoding putative 3-HP transporter(s). The tolerance improvement by yieP deletion was highly specific to 3-HP, among various C2–C4 organic acids. Mapping of YieP binding sites (ChIP-exo) coupled with transcriptomic profiling (RNA-seq) advocated seven potential genes/operons for further functional analysis. Among them, the yohJK operon, encoding for novel transmembrane proteins, was the most responsible for the improved 3-HP tolerance; deletion of yohJK reduced 3-HP tolerance regardless of yieP deletion, and their subsequent complementation fully restored the tolerance in both the wild-type and yieP deletion mutant. When determined by 3-HP-responsive biosensor, a drastic reduction of intracellular 3-HP was observed upon yieP deletion or yohJK overexpression, suggesting that yohJK encodes for novel 3-HP exporter(s)." @default.
• W3096988168 created "2020-11-09" @default.
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• W3096988168 date "2020-11-04" @default.
• W3096988168 modified "2023-10-11" @default.
• W3096988168 title "Systems evaluation reveals novel transporter YohJK renders 3-hydroxypropionate tolerance in Escherichia coli" @default.
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• W3096988168 doi "https://doi.org/10.1038/s41598-020-76120-3" @default.
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