FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3097021787> ?p ?o ?g. }

• W3097021787 abstract "Chronic inflammatory lung diseases such as chronic obstructive pulmonary disease (COPD) and asthma are progressive conditions affecting millions of people worldwide. In order to provide better therapeutic opportunities for COPD and asthma patients we need to explore and understand the contributions of the various cells and proteins involved in these diseases. The aim of the work described in this thesis was to study the expression and function of macrophage migration inhibitory factor (MIF) in COPD and asthma, as this protein influences cellular functions and immune responses and is said to be a pro-inflammatory mediator important in inflammatory lung disease.Here we integrated a critical review of the literature with an experimental approach and showed that while MIF is associated with chronic inflammatory lung diseases, its role is not necessarily proinflammatory, as previously suggested. We found that MIF expression in lung tissue of COPD patients is higher than in control individuals and that MIF expression may be caused by cellular senescence. Additionally we found that MIF expression in the lung is influenced by genetic elements, although not specifically in COPD patients. We also found that the MIF expression in the asthmatic lung is lower than in healthy conditions, and that its expression is associated with the presence of certain innate immune cells involved in allergic inflammatory responses.The work described in this thesis has established a basis for future studies that can unravel the versatile nature of MIF and investigate its true potential in therapeutic strategies for lung diseases." @default.
• W3097021787 created "2020-11-09" @default.
• W3097021787 creator A5062723470 @default.
• W3097021787 date "2020-10-13" @default.
• W3097021787 modified "2023-09-26" @default.
• W3097021787 title "The versatile nature of MIF (macrophage migration inhibitory factor) in chronic lung diseases" @default.
• W3097021787 cites W109149868 @default.
• W3097021787 cites W1482873758 @default.
• W3097021787 cites W1485469081 @default.
• W3097021787 cites W1487373628 @default.
• W3097021787 cites W1512506307 @default.
• W3097021787 cites W1520991027 @default.
• W3097021787 cites W1521804991 @default.
• W3097021787 cites W1522803047 @default.
• W3097021787 cites W1544230351 @default.
• W3097021787 cites W1565601828 @default.
• W3097021787 cites W1566903555 @default.
• W3097021787 cites W1588611448 @default.
• W3097021787 cites W1590900769 @default.
• W3097021787 cites W1593612940 @default.
• W3097021787 cites W1593855885 @default.
• W3097021787 cites W1604044665 @default.
• W3097021787 cites W1636849021 @default.
• W3097021787 cites W1640610491 @default.
• W3097021787 cites W1761501764 @default.
• W3097021787 cites W1787638040 @default.
• W3097021787 cites W1849900443 @default.
• W3097021787 cites W1854150933 @default.
• W3097021787 cites W1854779166 @default.
• W3097021787 cites W1901415212 @default.
• W3097021787 cites W1904869986 @default.
• W3097021787 cites W1909933445 @default.
• W3097021787 cites W1911456388 @default.
• W3097021787 cites W1934054475 @default.
• W3097021787 cites W1939198615 @default.
• W3097021787 cites W1951558217 @default.
• W3097021787 cites W1964369726 @default.
• W3097021787 cites W1966267138 @default.
• W3097021787 cites W1967545951 @default.
• W3097021787 cites W1968353658 @default.
• W3097021787 cites W1969038150 @default.
• W3097021787 cites W1969818245 @default.
• W3097021787 cites W1971811060 @default.
• W3097021787 cites W1971888466 @default.
• W3097021787 cites W1973621813 @default.
• W3097021787 cites W1973651197 @default.
• W3097021787 cites W1973753526 @default.
• W3097021787 cites W1974666859 @default.
• W3097021787 cites W1974693305 @default.
• W3097021787 cites W1975602384 @default.
• W3097021787 cites W1976646654 @default.
• W3097021787 cites W1978663882 @default.
• W3097021787 cites W1978678714 @default.
• W3097021787 cites W1981269419 @default.
• W3097021787 cites W1982202983 @default.
• W3097021787 cites W1982386486 @default.
• W3097021787 cites W1982641989 @default.
• W3097021787 cites W1984439708 @default.
• W3097021787 cites W1985502949 @default.
• W3097021787 cites W1985859986 @default.
• W3097021787 cites W1986308133 @default.
• W3097021787 cites W1987699155 @default.
• W3097021787 cites W1987803399 @default.
• W3097021787 cites W1991601117 @default.
• W3097021787 cites W1992800099 @default.
• W3097021787 cites W1993567092 @default.
• W3097021787 cites W1994001244 @default.
• W3097021787 cites W1994049688 @default.
• W3097021787 cites W1994793711 @default.
• W3097021787 cites W1995695950 @default.
• W3097021787 cites W1995910069 @default.
• W3097021787 cites W1995981970 @default.
• W3097021787 cites W1997082999 @default.
• W3097021787 cites W1998420703 @default.
• W3097021787 cites W1998455553 @default.
• W3097021787 cites W1998647423 @default.
• W3097021787 cites W2000906310 @default.
• W3097021787 cites W2001634895 @default.
• W3097021787 cites W2002945545 @default.
• W3097021787 cites W2004070471 @default.
• W3097021787 cites W2004635533 @default.
• W3097021787 cites W2007037927 @default.
• W3097021787 cites W2007821465 @default.
• W3097021787 cites W2010472544 @default.
• W3097021787 cites W2010484682 @default.
• W3097021787 cites W2010746507 @default.
• W3097021787 cites W2010876644 @default.
• W3097021787 cites W2010916313 @default.
• W3097021787 cites W2012919184 @default.
• W3097021787 cites W2014884192 @default.
• W3097021787 cites W2015047621 @default.
• W3097021787 cites W2018922281 @default.
• W3097021787 cites W2019954526 @default.
• W3097021787 cites W2020744745 @default.
• W3097021787 cites W2021888644 @default.
• W3097021787 cites W2022443457 @default.
• W3097021787 cites W2022790785 @default.
• W3097021787 cites W2023152671 @default.
• W3097021787 cites W2023503125 @default.
• W3097021787 cites W2023666964 @default.

• next