Matches in SemOpenAlex for { <https://semopenalex.org/work/W3097029494> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W3097029494 abstract "Single ventricle physiology is a complex disease state requiring multiple open-heart surgeries to achieve stable hemodynamics. For patients with abnormalities in the pulmonary arteries (PAs), these must be remedied before the patient can be a candidate for such palliations. Transcatheter techniques could rescue this subset of single ventricle patients through intervascular PA connections, allowing a high-risk population to ultimately achieve stable pulmonary blood flow. However, there is currently no in vitro platform to model transcatheter processes for anastomosis, particularly to palliate single ventricle defects. This project utilizes 3D bioprinting and perfusion bioreactor technologies to develop a functional in vitro biological device to model severely stenotic PAs of single ventricle patients. Human endothelial (ECs) & smooth muscle (SMCs) cells embedded in extracellular matrix bioink are used in a multi-material bioprinting approach to create 3D bilayer vascular structures with controlled geometry and flow. In collaboration with CHOA Cardiac Catheterization Laboratory , stent devices are deployed in the printed model to re-establish intervascular connection. Healthy, stenotic, and stented tissues are cultured via a bioreactor and analyzed for flow hemodynamics by echo PIV and 4D MR imaging. Cell viability, proliferation, and endothelialization of printed vessels, plus EC-SMC interplay were closely monitored pre- and post- anastomosis, to identify the effect of geometry and flow on cellular overgrowth. This advanced planning enables a subset of single ventricle patients, otherwise not eligible, to ultimately accept further palliative strategies." @default.
- W3097029494 created "2020-11-09" @default.
- W3097029494 creator A5000253400 @default.
- W3097029494 creator A5000535517 @default.
- W3097029494 creator A5013327604 @default.
- W3097029494 creator A5040472044 @default.
- W3097029494 creator A5042492602 @default.
- W3097029494 creator A5048473531 @default.
- W3097029494 creator A5050476826 @default.
- W3097029494 creator A5050552206 @default.
- W3097029494 creator A5058504093 @default.
- W3097029494 creator A5074077264 @default.
- W3097029494 creator A5076956472 @default.
- W3097029494 creator A5083363365 @default.
- W3097029494 creator A5088540735 @default.
- W3097029494 creator A5090798369 @default.
- W3097029494 date "2020-07-31" @default.
- W3097029494 modified "2023-09-26" @default.
- W3097029494 title "Abstract 405: A Personalized, 3D Printed <i>in vitro</i> Model of Vascular Anastomosis in Single Ventricle Heart Defects" @default.
- W3097029494 doi "https://doi.org/10.1161/res.127.suppl_1.405" @default.
- W3097029494 hasPublicationYear "2020" @default.
- W3097029494 type Work @default.
- W3097029494 sameAs 3097029494 @default.
- W3097029494 citedByCount "2" @default.
- W3097029494 countsByYear W30970294942021 @default.
- W3097029494 countsByYear W30970294942022 @default.
- W3097029494 crossrefType "journal-article" @default.
- W3097029494 hasAuthorship W3097029494A5000253400 @default.
- W3097029494 hasAuthorship W3097029494A5000535517 @default.
- W3097029494 hasAuthorship W3097029494A5013327604 @default.
- W3097029494 hasAuthorship W3097029494A5040472044 @default.
- W3097029494 hasAuthorship W3097029494A5042492602 @default.
- W3097029494 hasAuthorship W3097029494A5048473531 @default.
- W3097029494 hasAuthorship W3097029494A5050476826 @default.
- W3097029494 hasAuthorship W3097029494A5050552206 @default.
- W3097029494 hasAuthorship W3097029494A5058504093 @default.
- W3097029494 hasAuthorship W3097029494A5074077264 @default.
- W3097029494 hasAuthorship W3097029494A5076956472 @default.
- W3097029494 hasAuthorship W3097029494A5083363365 @default.
- W3097029494 hasAuthorship W3097029494A5088540735 @default.
- W3097029494 hasAuthorship W3097029494A5090798369 @default.
- W3097029494 hasConcept C126322002 @default.
- W3097029494 hasConcept C136229726 @default.
- W3097029494 hasConcept C141071460 @default.
- W3097029494 hasConcept C142724271 @default.
- W3097029494 hasConcept C164705383 @default.
- W3097029494 hasConcept C178853913 @default.
- W3097029494 hasConcept C2778921608 @default.
- W3097029494 hasConcept C3019308078 @default.
- W3097029494 hasConcept C71924100 @default.
- W3097029494 hasConcept C8443397 @default.
- W3097029494 hasConceptScore W3097029494C126322002 @default.
- W3097029494 hasConceptScore W3097029494C136229726 @default.
- W3097029494 hasConceptScore W3097029494C141071460 @default.
- W3097029494 hasConceptScore W3097029494C142724271 @default.
- W3097029494 hasConceptScore W3097029494C164705383 @default.
- W3097029494 hasConceptScore W3097029494C178853913 @default.
- W3097029494 hasConceptScore W3097029494C2778921608 @default.
- W3097029494 hasConceptScore W3097029494C3019308078 @default.
- W3097029494 hasConceptScore W3097029494C71924100 @default.
- W3097029494 hasConceptScore W3097029494C8443397 @default.
- W3097029494 hasIssue "Suppl_1" @default.
- W3097029494 hasLocation W30970294941 @default.
- W3097029494 hasOpenAccess W3097029494 @default.
- W3097029494 hasPrimaryLocation W30970294941 @default.
- W3097029494 hasRelatedWork W2035406542 @default.
- W3097029494 hasRelatedWork W2092630756 @default.
- W3097029494 hasRelatedWork W2316881821 @default.
- W3097029494 hasRelatedWork W2378358762 @default.
- W3097029494 hasRelatedWork W2391627734 @default.
- W3097029494 hasRelatedWork W2411389335 @default.
- W3097029494 hasRelatedWork W2417271704 @default.
- W3097029494 hasRelatedWork W2417677979 @default.
- W3097029494 hasRelatedWork W2440284157 @default.
- W3097029494 hasRelatedWork W2993248449 @default.
- W3097029494 hasVolume "127" @default.
- W3097029494 isParatext "false" @default.
- W3097029494 isRetracted "false" @default.
- W3097029494 magId "3097029494" @default.
- W3097029494 workType "article" @default.