FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3097037918> ?p ?o ?g. }

• W3097037918 endingPage "17" @default.
• W3097037918 startingPage "1" @default.
• W3097037918 abstract "Lymph node (LN) metastasis is a lethal independent risk factor for patients with bladder cancer (BLCA). Accurate evaluation of LN metastasis is of vital importance for disease staging, treatment selection, and prognosis prediction. Several histopathologic parameters are available to predict LN metastasis postoperatively. To date, medical imaging techniques have made a great contribution to preoperatively diagnosis of LN metastasis, but it also exhibits substantial false positives. Therefore, a reliable and robust method to preoperatively predict LN metastasis is urgently needed. Here, we selected 19 candidate genes related to epithelial-mesenchymal transition (EMT) across the LN metastasis samples, which was previously reported to be responsible for the subtype transition and correlation with malignancy and prognosis of BLCA, to establish an EMT-LN signature through LASSO logistic regression analysis. The EMT-LN signature could significantly predict LN metastasis with high accuracy in the TCGA-BLCA cohort, as well as several independent cohorts. As integrating with C3orf70 mutation, we developed an individualized prediction nomogram based on the EMT-LN signature. The nomogram exhibited good discrimination on LN metastasis status, with AUC of 71.7% and 75.9% in training and testing datasets of the TCGA-BLCA cohort. Moreover, the EMT-LN nomogram displayed good calibration with <math xmlns=http://www.w3.org/1998/Math/MathML id=M1> <mi>p</mi> <mo>></mo> <mn>0.05</mn> </math> in the Hosmer-Lemeshow goodness of fit test. Decision curve analysis (DCA) revealed that the EMT-LN nomogram was of high potential for clinical utility. In summary, we established an EMT-LN nomogram integrating an EMT-LN signature and C3orf70 mutation status, which acted as an easy-to-use tool to facilitate preoperative prediction of LN metastasis in BLCA individuals." @default.
• W3097037918 created "2020-11-09" @default.
• W3097037918 creator A5033039196 @default.
• W3097037918 creator A5043155449 @default.
• W3097037918 creator A5043199721 @default.
• W3097037918 creator A5049727703 @default.
• W3097037918 creator A5066934433 @default.
• W3097037918 creator A5088656853 @default.
• W3097037918 date "2020-11-03" @default.
• W3097037918 modified "2023-10-16" @default.
• W3097037918 title "An Epithelial-Mesenchymal Transition (EMT) Preoperative Nomogram for Prediction of Lymph Node Metastasis in Bladder Cancer (BLCA)" @default.
• W3097037918 cites W1480519071 @default.
• W3097037918 cites W1488856052 @default.
• W3097037918 cites W1503899947 @default.
• W3097037918 cites W1556125425 @default.
• W3097037918 cites W1806851719 @default.
• W3097037918 cites W1966116114 @default.
• W3097037918 cites W1983950941 @default.
• W3097037918 cites W2002883782 @default.
• W3097037918 cites W2003385691 @default.
• W3097037918 cites W2005040920 @default.
• W3097037918 cites W2009720434 @default.
• W3097037918 cites W2016537592 @default.
• W3097037918 cites W2017634789 @default.
• W3097037918 cites W2031726925 @default.
• W3097037918 cites W2035062922 @default.
• W3097037918 cites W2035618305 @default.
• W3097037918 cites W2068482988 @default.
• W3097037918 cites W2073995462 @default.
• W3097037918 cites W2076583198 @default.
• W3097037918 cites W2081810298 @default.
• W3097037918 cites W2091415498 @default.
• W3097037918 cites W2097016282 @default.
• W3097037918 cites W2097705796 @default.
• W3097037918 cites W2099144920 @default.
• W3097037918 cites W2100480913 @default.
• W3097037918 cites W2109278582 @default.
• W3097037918 cites W2109581208 @default.
• W3097037918 cites W2110643416 @default.
• W3097037918 cites W2116634113 @default.
• W3097037918 cites W2117427924 @default.
• W3097037918 cites W2123161437 @default.
• W3097037918 cites W2125053924 @default.
• W3097037918 cites W2130410032 @default.
• W3097037918 cites W2140408271 @default.
• W3097037918 cites W2145684092 @default.
• W3097037918 cites W2146646572 @default.
• W3097037918 cites W2146684961 @default.
• W3097037918 cites W2146712391 @default.
• W3097037918 cites W2151748218 @default.
• W3097037918 cites W2230320310 @default.
• W3097037918 cites W2308167615 @default.
• W3097037918 cites W2406250479 @default.
• W3097037918 cites W2570682666 @default.
• W3097037918 cites W2582671354 @default.
• W3097037918 cites W2593566229 @default.
• W3097037918 cites W2603914834 @default.
• W3097037918 cites W2606173101 @default.
• W3097037918 cites W2618241983 @default.
• W3097037918 cites W2726861941 @default.
• W3097037918 cites W2763670669 @default.
• W3097037918 cites W2790743957 @default.
• W3097037918 cites W2802492956 @default.
• W3097037918 cites W2810600065 @default.
• W3097037918 cites W2885554167 @default.
• W3097037918 cites W2888969259 @default.
• W3097037918 cites W2889646458 @default.
• W3097037918 cites W2896872272 @default.
• W3097037918 cites W2939681313 @default.
• W3097037918 cites W2944137325 @default.
• W3097037918 cites W2945162628 @default.
• W3097037918 cites W2980557044 @default.
• W3097037918 cites W2981742231 @default.
• W3097037918 cites W3023288864 @default.
• W3097037918 cites W3038003095 @default.
• W3097037918 cites W4211053712 @default.
• W3097037918 cites W4294541781 @default.
• W3097037918 doi "https://doi.org/10.1155/2020/8833972" @default.
• W3097037918 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7656235" @default.
• W3097037918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33204364" @default.
• W3097037918 hasPublicationYear "2020" @default.
• W3097037918 type Work @default.
• W3097037918 sameAs 3097037918 @default.
• W3097037918 citedByCount "5" @default.
• W3097037918 countsByYear W30970379182021 @default.
• W3097037918 countsByYear W30970379182022 @default.
• W3097037918 countsByYear W30970379182023 @default.
• W3097037918 crossrefType "journal-article" @default.
• W3097037918 hasAuthorship W3097037918A5033039196 @default.
• W3097037918 hasAuthorship W3097037918A5043155449 @default.
• W3097037918 hasAuthorship W3097037918A5043199721 @default.
• W3097037918 hasAuthorship W3097037918A5049727703 @default.
• W3097037918 hasAuthorship W3097037918A5066934433 @default.
• W3097037918 hasAuthorship W3097037918A5088656853 @default.
• W3097037918 hasBestOaLocation W30970379181 @default.
• W3097037918 hasConcept C121608353 @default.
• W3097037918 hasConcept C126322002 @default.
• W3097037918 hasConcept C136764020 @default.

• next