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- W3097057532 abstract "A highly enantioselective [3+2] annulation of 3-((2-oxoindolin-3-yl)oxy)acrylates with isoxazol-5(4H)-ones has been accomplished by squaramide-catalyzed cascade Michael/Michael addition reactions under mild conditions. The corresponding isoxazolone-spirooxindoles with four continuous stereocenters were obtained in moderate to high yields with excellent stereoselectivities (up to >20:1 dr, 97% ee). The synthetic practicality of this methodology was illustrated by performing the reaction on a gram scale with the same efficiency and stereoselectivity. Meanwhile, the isoxazol-5(4H)-one ring could be opened by the reaction with iron powder and ammonium chloride, and the corresponding acyl derivative can be obtained with a maintained yield and stereoselectivity." @default.
- W3097057532 created "2020-11-09" @default.
- W3097057532 creator A5007229671 @default.
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- W3097057532 date "2020-11-03" @default.
- W3097057532 modified "2023-10-16" @default.
- W3097057532 title "Highly Diastereo- and Enantioselective Synthesis of Isoxazolone-Spirooxindoles via Squaramide-Catalyzed Cascade Michael/Michael Addition Reactions" @default.
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- W3097057532 doi "https://doi.org/10.1021/acs.joc.0c02150" @default.
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