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• W3097063735 abstract "The regenerative capacity of the peripheral nervous system after an injury is limited, and a complete function is not recovered, mainly due to the loss of nerve tissue after the injury that causes a separation between the nerve ends and to the disorganized and intermingled growth of sensory and motor nerve fibers that cause erroneous reinnervations. Even though the development of biomaterials is a very promising field, today no significant results have been achieved. In this work, we study not only the characteristics that should have the support that will allow the growth of nerve fibers, but also the molecular profile necessary for a specific guidance. To do this, we carried out an exhaustive study of the molecular profile present during the regeneration of the sensory and motor fibers separately, as well as of the effect obtained by the administration and inhibition of different factors involved in the regeneration. In addition, we offer a complete design of the ideal characteristics of a biomaterial, which allows the growth of the sensory and motor neurons in a differentiated way, indicating (1) size and characteristics of the material; (2) necessity to act at the microlevel, on small groups of neurons; (3) combination of molecules and specific substrates; and (4) temporal profile of those molecules expression throughout the regeneration process. The importance of the design we offer is that it respects the complexity and characteristics of the regeneration process; it indicates the appropriate temporal conditions of molecular expression, in order to obtain a synergistic effect; it takes into account the importance of considering the process at the group of neuron level; and it gives an answer to the main limitations in the current studies." @default.
• W3097063735 created "2020-11-09" @default.
• W3097063735 creator A5009486584 @default.
• W3097063735 creator A5020913115 @default.
• W3097063735 creator A5033640650 @default.
• W3097063735 creator A5037991466 @default.
• W3097063735 creator A5045098910 @default.
• W3097063735 creator A5066505528 @default.
• W3097063735 creator A5075743091 @default.
• W3097063735 date "2020-11-03" @default.
• W3097063735 modified "2023-10-02" @default.
• W3097063735 title "Biomimetic Approaches for Separated Regeneration of Sensory and Motor Fibers in Amputee People: Necessary Conditions for Functional Integration of Sensory–Motor Prostheses With the Peripheral Nerves" @default.
• W3097063735 cites W1124138708 @default.
• W3097063735 cites W132811261 @default.
• W3097063735 cites W1510769829 @default.
• W3097063735 cites W1543041372 @default.
• W3097063735 cites W1697170845 @default.
• W3097063735 cites W1741817323 @default.
• W3097063735 cites W1766166977 @default.
• W3097063735 cites W1768356346 @default.
• W3097063735 cites W1784352764 @default.
• W3097063735 cites W186197308 @default.
• W3097063735 cites W1885786751 @default.
• W3097063735 cites W1886219881 @default.
• W3097063735 cites W1964810819 @default.
• W3097063735 cites W1965261497 @default.
• W3097063735 cites W1965462287 @default.
• W3097063735 cites W1967679504 @default.
• W3097063735 cites W1969821478 @default.
• W3097063735 cites W1970534832 @default.
• W3097063735 cites W1970754370 @default.
• W3097063735 cites W1970771505 @default.
• W3097063735 cites W1971665625 @default.
• W3097063735 cites W1973043293 @default.
• W3097063735 cites W1975409144 @default.
• W3097063735 cites W1976328687 @default.
• W3097063735 cites W1977513341 @default.
• W3097063735 cites W1977700531 @default.
• W3097063735 cites W1979795035 @default.
• W3097063735 cites W1983090422 @default.
• W3097063735 cites W1983955912 @default.
• W3097063735 cites W1984614679 @default.
• W3097063735 cites W1985525878 @default.
• W3097063735 cites W1987014667 @default.
• W3097063735 cites W1987949333 @default.
• W3097063735 cites W1988269444 @default.
• W3097063735 cites W1988713855 @default.
• W3097063735 cites W1990474391 @default.
• W3097063735 cites W1991833060 @default.
• W3097063735 cites W1993563727 @default.
• W3097063735 cites W1994332869 @default.
• W3097063735 cites W1997028439 @default.
• W3097063735 cites W1999639720 @default.
• W3097063735 cites W2001810227 @default.
• W3097063735 cites W2005870075 @default.
• W3097063735 cites W2005992918 @default.
• W3097063735 cites W2008891455 @default.
• W3097063735 cites W2010219735 @default.
• W3097063735 cites W2010836166 @default.
• W3097063735 cites W2011023406 @default.
• W3097063735 cites W2011856091 @default.
• W3097063735 cites W2012100020 @default.
• W3097063735 cites W2013632655 @default.
• W3097063735 cites W2014891480 @default.
• W3097063735 cites W2019309424 @default.
• W3097063735 cites W2019602403 @default.
• W3097063735 cites W2020394368 @default.
• W3097063735 cites W2022308075 @default.
• W3097063735 cites W2024156553 @default.
• W3097063735 cites W2026799007 @default.
• W3097063735 cites W2027464335 @default.
• W3097063735 cites W2028531720 @default.
• W3097063735 cites W2028840661 @default.
• W3097063735 cites W2028895530 @default.
• W3097063735 cites W2030807678 @default.
• W3097063735 cites W2031342438 @default.
• W3097063735 cites W2033712349 @default.
• W3097063735 cites W2035913395 @default.
• W3097063735 cites W2036557453 @default.
• W3097063735 cites W2036600625 @default.
• W3097063735 cites W2038865734 @default.
• W3097063735 cites W2040388528 @default.
• W3097063735 cites W2042617428 @default.
• W3097063735 cites W2045073848 @default.
• W3097063735 cites W2045369581 @default.
• W3097063735 cites W2045495188 @default.
• W3097063735 cites W2046196191 @default.
• W3097063735 cites W2046554331 @default.
• W3097063735 cites W2048218527 @default.
• W3097063735 cites W2052424792 @default.
• W3097063735 cites W2054131318 @default.
• W3097063735 cites W2054174398 @default.
• W3097063735 cites W2054365884 @default.
• W3097063735 cites W2055526192 @default.
• W3097063735 cites W2059493197 @default.
• W3097063735 cites W2059720153 @default.
• W3097063735 cites W2066342229 @default.
• W3097063735 cites W2068357442 @default.
• W3097063735 cites W2072159990 @default.
• W3097063735 cites W2072586013 @default.

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