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- W3097125859 abstract "Clear cell renal cell carcinoma (ccRCC) is characterized by high histone deacetylase (HDAC) activity triggering both cell motility and the development of metastasis. Therefore, there is an unmet need to establish innovative strategies to advance the use of HDAC inhibitors (HDACIs). We selected a set of tyrosine kinase inhibitors (TKIs) and HDACIs to test them in combination, using the validated therapeutically guided multidrug optimization (TGMO) technique based on experimental testing and in silico data modeling. We determined a synergistic low-dose three-drug combination decreasing the cell metabolic activity in metastatic ccRCC cells, Caki-1, by over 80%. This drug combination induced apoptosis and showed anti-angiogenic activity, both in original Caki-1 and in sunitinib-resistant Caki-1 cells. Through phosphoproteomic analysis, we revealed additional targets to improve the translation of this combination in 3-D (co-)culture systems. Cell–cell and cell–environment interactions increased, reverting the invasive and metastatic phenotype of Caki-1 cells. Our data suggest that our optimized low-dose drug combination is highly effective in complex in vitro settings and promotes the activity of HDACIs." @default.
- W3097125859 created "2020-11-09" @default.
- W3097125859 creator A5018213217 @default.
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- W3097125859 creator A5091013530 @default.
- W3097125859 date "2020-10-28" @default.
- W3097125859 modified "2023-10-07" @default.
- W3097125859 title "Optimized Combination of HDACI and TKI Efficiently Inhibits Metabolic Activity in Renal Cell Carcinoma and Overcomes Sunitinib Resistance" @default.
- W3097125859 cites W1667020473 @default.
- W3097125859 cites W1742190155 @default.
- W3097125859 cites W1818470125 @default.
- W3097125859 cites W1869249629 @default.
- W3097125859 cites W1965331098 @default.
- W3097125859 cites W1982276424 @default.
- W3097125859 cites W1984984885 @default.
- W3097125859 cites W1989854110 @default.
- W3097125859 cites W1990916130 @default.
- W3097125859 cites W1998203489 @default.
- W3097125859 cites W2001488800 @default.
- W3097125859 cites W2002265297 @default.
- W3097125859 cites W2004281677 @default.
- W3097125859 cites W2008629746 @default.
- W3097125859 cites W2009823821 @default.
- W3097125859 cites W2016091072 @default.
- W3097125859 cites W2022859954 @default.
- W3097125859 cites W2027711761 @default.
- W3097125859 cites W2044510096 @default.
- W3097125859 cites W2051257692 @default.
- W3097125859 cites W2056181814 @default.
- W3097125859 cites W2065583248 @default.
- W3097125859 cites W2078449820 @default.
- W3097125859 cites W2086756744 @default.
- W3097125859 cites W2092422799 @default.
- W3097125859 cites W2092684062 @default.
- W3097125859 cites W2095249551 @default.
- W3097125859 cites W2097630651 @default.
- W3097125859 cites W2097863827 @default.
- W3097125859 cites W2099915065 @default.
- W3097125859 cites W2104425103 @default.
- W3097125859 cites W2105906697 @default.
- W3097125859 cites W2108578850 @default.
- W3097125859 cites W2111073459 @default.
- W3097125859 cites W2116490375 @default.
- W3097125859 cites W2117365333 @default.
- W3097125859 cites W2127283584 @default.
- W3097125859 cites W2128855114 @default.
- W3097125859 cites W2136102697 @default.
- W3097125859 cites W2142233318 @default.
- W3097125859 cites W2144539352 @default.
- W3097125859 cites W2145578524 @default.
- W3097125859 cites W2146315158 @default.
- W3097125859 cites W2146416540 @default.
- W3097125859 cites W2148309788 @default.
- W3097125859 cites W2149379768 @default.
- W3097125859 cites W2165638033 @default.
- W3097125859 cites W2170839629 @default.
- W3097125859 cites W2175192779 @default.
- W3097125859 cites W2177591543 @default.
- W3097125859 cites W2194348484 @default.
- W3097125859 cites W2233789132 @default.
- W3097125859 cites W2279626754 @default.
- W3097125859 cites W2336296838 @default.
- W3097125859 cites W2391847988 @default.
- W3097125859 cites W2396108323 @default.
- W3097125859 cites W2415368345 @default.
- W3097125859 cites W2422889450 @default.
- W3097125859 cites W2471908424 @default.
- W3097125859 cites W2514024468 @default.
- W3097125859 cites W2537262865 @default.
- W3097125859 cites W2552327471 @default.
- W3097125859 cites W2564862421 @default.
- W3097125859 cites W2578387871 @default.
- W3097125859 cites W2589656556 @default.
- W3097125859 cites W2600452401 @default.
- W3097125859 cites W2604616761 @default.
- W3097125859 cites W2619807356 @default.
- W3097125859 cites W2620472170 @default.
- W3097125859 cites W2724336500 @default.
- W3097125859 cites W2726542547 @default.
- W3097125859 cites W2742545337 @default.
- W3097125859 cites W2759659489 @default.
- W3097125859 cites W2760753980 @default.
- W3097125859 cites W2773242491 @default.
- W3097125859 cites W2790081045 @default.
- W3097125859 cites W2792013220 @default.
- W3097125859 cites W2792597015 @default.
- W3097125859 cites W2792676381 @default.
- W3097125859 cites W2795208162 @default.
- W3097125859 cites W2803326208 @default.
- W3097125859 cites W2807109438 @default.
- W3097125859 cites W2891207807 @default.
- W3097125859 cites W2903775276 @default.
- W3097125859 cites W2912699041 @default.
- W3097125859 cites W2914771174 @default.