Matches in SemOpenAlex for { <https://semopenalex.org/work/W3097134310> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W3097134310 endingPage "365" @default.
- W3097134310 startingPage "358" @default.
- W3097134310 abstract "Previously, we reported that microglial expression of histone deacetylases 1 and 2 (Hdac1 and Hdac2) is required for microglial maturation and modulates disease progression in a mouse model of Alzheimer’s disease. Here, we analyze the role of microglial expression of Hdac1 and Hdac2 in another disease paradigm, namely experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis. The aim of this study was to ascertain whether microglial expression of these two epigenetic regulators modulates disease progression in the context of autoimmune disease. Hdac1 and Hdac2 were knocked out either individually or in combination using a microglia-specific, tamoxifen-inducible Cre-deleter line (Cx3cr1-CreERT2). The clinical course as well as histopathological changes during EAE were assessed in adult mice lacking microglial expression of these genes. Overall, no differences in disease onset, progression or severity could be detected in mice lacking microglial expression of either one or both of Hdac1 and Hdac2 genes. Similarly, the histopathology showed no differences in lymphocyte or macrophage infiltration or demyelination in either of the analyzed groups. As such, we conclude that unlike in neurodegenerative disease, microglial expression of Hdac1 and Hdac2 does not play a role in EAE." @default.
- W3097134310 created "2020-11-09" @default.
- W3097134310 creator A5034599881 @default.
- W3097134310 creator A5050768459 @default.
- W3097134310 creator A5077227216 @default.
- W3097134310 date "2020-10-31" @default.
- W3097134310 modified "2023-10-14" @default.
- W3097134310 title "Microglial Expression of Hdac1 and Hdac2 is Dispensable for Experimental Autoimmune Encephalomyelitis (EAE) Progression" @default.
- W3097134310 cites W1498387932 @default.
- W3097134310 cites W1988347844 @default.
- W3097134310 cites W1992432201 @default.
- W3097134310 cites W2011718960 @default.
- W3097134310 cites W2019604999 @default.
- W3097134310 cites W2037750523 @default.
- W3097134310 cites W2048944834 @default.
- W3097134310 cites W2099013228 @default.
- W3097134310 cites W2114275123 @default.
- W3097134310 cites W2151003930 @default.
- W3097134310 cites W2153406260 @default.
- W3097134310 cites W2200708130 @default.
- W3097134310 cites W2651656482 @default.
- W3097134310 cites W2760172662 @default.
- W3097134310 cites W2774947569 @default.
- W3097134310 cites W2786979675 @default.
- W3097134310 cites W2789949980 @default.
- W3097134310 cites W2796983933 @default.
- W3097134310 cites W2893189654 @default.
- W3097134310 cites W2913221496 @default.
- W3097134310 cites W2914756534 @default.
- W3097134310 cites W2944502542 @default.
- W3097134310 cites W2954965237 @default.
- W3097134310 cites W2978969137 @default.
- W3097134310 cites W3012139047 @default.
- W3097134310 cites W4296816736 @default.
- W3097134310 doi "https://doi.org/10.3390/j3040028" @default.
- W3097134310 hasPublicationYear "2020" @default.
- W3097134310 type Work @default.
- W3097134310 sameAs 3097134310 @default.
- W3097134310 citedByCount "0" @default.
- W3097134310 crossrefType "journal-article" @default.
- W3097134310 hasAuthorship W3097134310A5034599881 @default.
- W3097134310 hasAuthorship W3097134310A5050768459 @default.
- W3097134310 hasAuthorship W3097134310A5077227216 @default.
- W3097134310 hasBestOaLocation W30971343101 @default.
- W3097134310 hasConcept C104317684 @default.
- W3097134310 hasConcept C203014093 @default.
- W3097134310 hasConcept C2776914184 @default.
- W3097134310 hasConcept C2778305200 @default.
- W3097134310 hasConcept C2778486448 @default.
- W3097134310 hasConcept C2779830541 @default.
- W3097134310 hasConcept C2780640218 @default.
- W3097134310 hasConcept C41091548 @default.
- W3097134310 hasConcept C54355233 @default.
- W3097134310 hasConcept C64927066 @default.
- W3097134310 hasConcept C71723506 @default.
- W3097134310 hasConcept C85240754 @default.
- W3097134310 hasConcept C86803240 @default.
- W3097134310 hasConceptScore W3097134310C104317684 @default.
- W3097134310 hasConceptScore W3097134310C203014093 @default.
- W3097134310 hasConceptScore W3097134310C2776914184 @default.
- W3097134310 hasConceptScore W3097134310C2778305200 @default.
- W3097134310 hasConceptScore W3097134310C2778486448 @default.
- W3097134310 hasConceptScore W3097134310C2779830541 @default.
- W3097134310 hasConceptScore W3097134310C2780640218 @default.
- W3097134310 hasConceptScore W3097134310C41091548 @default.
- W3097134310 hasConceptScore W3097134310C54355233 @default.
- W3097134310 hasConceptScore W3097134310C64927066 @default.
- W3097134310 hasConceptScore W3097134310C71723506 @default.
- W3097134310 hasConceptScore W3097134310C85240754 @default.
- W3097134310 hasConceptScore W3097134310C86803240 @default.
- W3097134310 hasIssue "4" @default.
- W3097134310 hasLocation W30971343101 @default.
- W3097134310 hasOpenAccess W3097134310 @default.
- W3097134310 hasPrimaryLocation W30971343101 @default.
- W3097134310 hasRelatedWork W1763258797 @default.
- W3097134310 hasRelatedWork W2186493062 @default.
- W3097134310 hasRelatedWork W2465147644 @default.
- W3097134310 hasRelatedWork W2789748343 @default.
- W3097134310 hasRelatedWork W2945306750 @default.
- W3097134310 hasRelatedWork W2982478683 @default.
- W3097134310 hasRelatedWork W3184897000 @default.
- W3097134310 hasRelatedWork W3197136220 @default.
- W3097134310 hasRelatedWork W4309098871 @default.
- W3097134310 hasRelatedWork W4319433888 @default.
- W3097134310 hasVolume "3" @default.
- W3097134310 isParatext "false" @default.
- W3097134310 isRetracted "false" @default.
- W3097134310 magId "3097134310" @default.
- W3097134310 workType "article" @default.