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- W3097146219 abstract "To discover effective drugs for COVID-19 treatment amongst already clinically approved drugs, we developed a high throughput screening assay for SARS-CoV-2 virus entry inhibitors using SARS2-S pseudotyped virus. An approved drug library of 1800 small molecular drugs was screened for SARS2 entry inhibitors and 15 active drugs were identified as specific SARS2-S pseudovirus entry inhibitors. Antiviral tests using native SARS-CoV-2 virus in Vero E6 cells confirmed that 7 of these drugs (clemastine, amiodarone, trimeprazine, bosutinib, toremifene, flupenthixol, and azelastine) significantly inhibited SARS2 replication, reducing supernatant viral RNA load with a promising level of activity. Three of the drugs were classified as histamine receptor antagonists with clemastine showing the strongest anti-SARS2 activity (EC50 = 0.95 ± 0.83 µM). Our work suggests that these 7 drugs could enter into further in vivo studies and clinical investigations for COVID-19 treatment." @default.
- W3097146219 created "2020-11-09" @default.
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- W3097146219 date "2020-10-28" @default.
- W3097146219 modified "2023-10-18" @default.
- W3097146219 title "Identification of SARS-CoV-2 entry inhibitors among already approved drugs" @default.
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- W3097146219 doi "https://doi.org/10.1038/s41401-020-00556-6" @default.
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