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- W3097153535 abstract "Significance Pheno-RNA is a new idea/method to identify genes important for a phenotype. It involves 1) generating a phenotypic series that involves different experimental conditions to yield a measurable phenotype, 2) performing transcriptional profiling under all the conditions, and 3) correlating gene expression profiles with phenotypic strength. Using this method, we identified ∼200 genes whose expression profiles over 17 conditions show a remarkably high correlation to the level of transformation. As expected, these ∼200 genes are enriched in biological categories important for transformation. Within these categories, some genes have very high correlations with the transformation phenotype, whereas others do not. Ninety genes with high correlations have not been previously linked to cancer, suggesting heretofore unknown genes with a role in cancer." @default.
- W3097153535 created "2020-11-09" @default.
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- W3097153535 date "2020-11-03" @default.
- W3097153535 modified "2023-10-11" @default.
- W3097153535 title "Pheno-RNA, a method to associate genes with a specific phenotype, identifies genes linked to cellular transformation" @default.
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- W3097153535 doi "https://doi.org/10.1073/pnas.2014165117" @default.
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