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- W3097180994 abstract "We developed a pH-activatable cell-penetrating peptide dimer LH2 with histidine residues, which can penetrate cells, specifically in weak acidic conditions, even at few tens of nanomolar concentrations. LH2 effectively delivered paclitaxel into triple-negative breast cancer cells, MDA-MB-231, via formation of non-covalent complexes (PTX-LH2(M)) or covalent conjugates (PTX-LH2(C)). Moreover, LH2 showed prolonged circulation in the body and enhanced accumulation in tumors. Both PTX-LH2(M) and PTX-LH2(C) showed strong antitumor effects in a triple-negative breast cancer grafted mouse model at an extremely low dosage." @default.
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- W3097180994 date "2021-02-01" @default.
- W3097180994 modified "2023-10-09" @default.
- W3097180994 title "pH-Activatable cell penetrating peptide dimers for potent delivery of anticancer drug to triple-negative breast cancer" @default.
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- W3097180994 doi "https://doi.org/10.1016/j.jconrel.2020.10.063" @default.
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