FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3097208183> ?p ?o ?g. }

• W3097208183 abstract "To better understand a role of eIF4E S209 in oncogenic translation, we generated EIF4E S209A/+ heterozygous knockin (4EKI) HCT 116 human colorectal cancer (CRC) cells. 4EKI had little impact on total eIF4E levels, cap binding or global translation, but markedly reduced HCT 116 cell growth in spheroids and mice, and CRC organoid growth. 4EKI strongly inhibited Myc and ATF4 translation, the integrated stress response (ISR)-dependent glutamine metabolic signature, AKT activation and proliferation in vivo. 4EKI inhibited polyposis in Apc Min/+ mice by suppressing Myc protein and AKT activation. Furthermore, p-eIF4E was highly elevated in CRC precursor lesions in mouse and human. p-eIF4E cooperated with mutant KRAS to promote Myc and ISR-dependent glutamine addiction in various CRC cell lines, characterized by increased cell death, transcriptomic heterogeneity and immune suppression upon deprivation. These findings demonstrate a critical role of eIF4E S209-dependent translation in Myc and stress-driven oncogenesis and as a potential therapeutic vulnerability." @default.
• W3097208183 created "2020-11-09" @default.
• W3097208183 creator A5015775150 @default.
• W3097208183 creator A5018516855 @default.
• W3097208183 creator A5019957951 @default.
• W3097208183 creator A5026394708 @default.
• W3097208183 creator A5028963094 @default.
• W3097208183 creator A5030927081 @default.
• W3097208183 creator A5046515259 @default.
• W3097208183 creator A5050299013 @default.
• W3097208183 creator A5052511823 @default.
• W3097208183 creator A5066737350 @default.
• W3097208183 creator A5073098968 @default.
• W3097208183 creator A5076776163 @default.
• W3097208183 creator A5078996254 @default.
• W3097208183 creator A5086910766 @default.
• W3097208183 creator A5091901193 @default.
• W3097208183 date "2020-11-02" @default.
• W3097208183 modified "2023-10-12" @default.
• W3097208183 title "eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis" @default.
• W3097208183 cites W1574085794 @default.
• W3097208183 cites W1969311457 @default.
• W3097208183 cites W1970766774 @default.
• W3097208183 cites W1973256886 @default.
• W3097208183 cites W1975172131 @default.
• W3097208183 cites W1986308117 @default.
• W3097208183 cites W2001399725 @default.
• W3097208183 cites W2002404925 @default.
• W3097208183 cites W2005176113 @default.
• W3097208183 cites W2005234434 @default.
• W3097208183 cites W2013996883 @default.
• W3097208183 cites W2021669986 @default.
• W3097208183 cites W2032489735 @default.
• W3097208183 cites W2032603938 @default.
• W3097208183 cites W2035863659 @default.
• W3097208183 cites W2038146634 @default.
• W3097208183 cites W2042539754 @default.
• W3097208183 cites W2044433401 @default.
• W3097208183 cites W2050345155 @default.
• W3097208183 cites W2052001124 @default.
• W3097208183 cites W2052487210 @default.
• W3097208183 cites W2052677854 @default.
• W3097208183 cites W2056036930 @default.
• W3097208183 cites W2062413735 @default.
• W3097208183 cites W2074471441 @default.
• W3097208183 cites W2077813812 @default.
• W3097208183 cites W2080534618 @default.
• W3097208183 cites W2087200546 @default.
• W3097208183 cites W2087962053 @default.
• W3097208183 cites W2091820067 @default.
• W3097208183 cites W2102889876 @default.
• W3097208183 cites W2112968535 @default.
• W3097208183 cites W2117692326 @default.
• W3097208183 cites W2118054479 @default.
• W3097208183 cites W2127848114 @default.
• W3097208183 cites W2131632095 @default.
• W3097208183 cites W2141459186 @default.
• W3097208183 cites W2148220182 @default.
• W3097208183 cites W2148915086 @default.
• W3097208183 cites W2152066692 @default.
• W3097208183 cites W2152309111 @default.
• W3097208183 cites W2159582900 @default.
• W3097208183 cites W2163235555 @default.
• W3097208183 cites W2169589032 @default.
• W3097208183 cites W2464715097 @default.
• W3097208183 cites W2557113327 @default.
• W3097208183 cites W2562554297 @default.
• W3097208183 cites W2586097538 @default.
• W3097208183 cites W2606047684 @default.
• W3097208183 cites W2621232571 @default.
• W3097208183 cites W2624068238 @default.
• W3097208183 cites W2692768525 @default.
• W3097208183 cites W2725383737 @default.
• W3097208183 cites W2762079818 @default.
• W3097208183 cites W2787166138 @default.
• W3097208183 cites W2788237018 @default.
• W3097208183 cites W2791998267 @default.
• W3097208183 cites W2890683593 @default.
• W3097208183 cites W2908902954 @default.
• W3097208183 cites W2911188335 @default.
• W3097208183 cites W2915054797 @default.
• W3097208183 cites W2944829368 @default.
• W3097208183 cites W2988704237 @default.
• W3097208183 cites W3007097494 @default.
• W3097208183 cites W3013477457 @default.
• W3097208183 cites W3028396238 @default.
• W3097208183 cites W4235027475 @default.
• W3097208183 cites W4237335579 @default.
• W3097208183 cites W4249877820 @default.
• W3097208183 doi "https://doi.org/10.7554/elife.60151" @default.
• W3097208183 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7665890" @default.
• W3097208183 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33135632" @default.
• W3097208183 hasPublicationYear "2020" @default.
• W3097208183 type Work @default.
• W3097208183 sameAs 3097208183 @default.
• W3097208183 citedByCount "16" @default.
• W3097208183 countsByYear W30972081832021 @default.
• W3097208183 countsByYear W30972081832022 @default.
• W3097208183 countsByYear W30972081832023 @default.
• W3097208183 crossrefType "journal-article" @default.

• next