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- W3097252308 endingPage "3589" @default.
- W3097252308 startingPage "3589" @default.
- W3097252308 abstract "T-cell replete Haploidentical stem cell transplantation (Haplo-SCT) with Post-transplant cyclophosphamide (PT-Cy) is an emerging therapeutic option for patients with advanced relapsed or refractory lymphoma. The feasibility of this platform is supported by several retrospective studies showing a toxicity profile that is improved relative to umbilical cord blood and mismatched unrelated donor (UD) transplant and comparable to matched unrelated donor transplant. In particular, cumulative incidence of chronic graft-versus-host disease (GVHD) is reduced after Haplo-SCT relative to UD and matched related donor (MRD) transplant thanks to PT-Cy employed as GVHD prophylaxis. This achievement, together with a similar incidence of acute GVHD and disease relapse, results in a promising advantage of Haplo-SCT in terms of relapse-free/GVHD free survival. Unmet needs of the Haplo-SCT platform are represented by the persistence of a not negligible rate of non-relapse mortality, especially due to infections and disease relapse. Future efforts are warranted in order to reduce life-threatening infections and to employ Halo-SCT with PT-Cy as a platform to build new immunotherapeutic strategies." @default.
- W3097252308 created "2020-11-09" @default.
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- W3097252308 date "2020-11-07" @default.
- W3097252308 modified "2023-09-24" @default.
- W3097252308 title "Haploidentical Stem Cell Transplantation in Lymphomas—Expectations and Pitfalls" @default.
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- W3097252308 doi "https://doi.org/10.3390/jcm9113589" @default.
- W3097252308 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7695017" @default.
- W3097252308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33171719" @default.
- W3097252308 hasPublicationYear "2020" @default.
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