FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3097279097> ?p ?o ?g. }

• W3097279097 endingPage "173699" @default.
• W3097279097 startingPage "173699" @default.
• W3097279097 abstract "The time-course of pulmonary arterial hypertension in the monocrotaline (MCT) model was investigated. Male rats were divided into two groups: MCT (received a 60 mg/kg i.p. injection) and control (received saline). The MCT and control groups were further divided into three cohorts, based on the follow-up interval: 1, 2, and 3 weeks. Right ventricle (RV) catheterization was performed and RV hypertrophy (RVH) was estimated. The lungs were used for biochemical, histological, molecular, and immunohistochemical analysis, while pulmonary artery rings were used for vascular reactivity. MCT promoted lung perivascular edema, inflammatory cells exudation, greater neutrophils and lymphocytes profile, and arteriolar wall thickness, compared to CTR group. Increases in pulmonary artery pressure and in RVH were observed in the MCT 2- and 3-week groups. The first week was marked by the presence of nitrosative stress (50% moderate and 33% accentuated staining by nitrotyrosine). These alterations lead to an adaptation of NO production by NO synthase activity after 2 weeks. Oxidative stress was evident in the third week, probably by an imbalance between endothelin-1 receptors, resulting in extracellular matrix remodeling, endothelial dysfunction, and RVH. Also, it was found a reduced pulmonary arterial vasodilatory response to acetylcholine after 2 (55%) and 3 (45%) weeks in MCT groups. The relevance of this study is precisely to show that nitrosative and oxidative stress predominate in distinct time windows of the disease progression." @default.
• W3097279097 created "2020-11-09" @default.
• W3097279097 creator A5007836955 @default.
• W3097279097 creator A5023193135 @default.
• W3097279097 creator A5030209314 @default.
• W3097279097 creator A5031009446 @default.
• W3097279097 creator A5037405233 @default.
• W3097279097 creator A5044815211 @default.
• W3097279097 creator A5046929223 @default.
• W3097279097 creator A5055347418 @default.
• W3097279097 creator A5078183327 @default.
• W3097279097 creator A5080083870 @default.
• W3097279097 creator A5084149872 @default.
• W3097279097 creator A5089277835 @default.
• W3097279097 creator A5090516833 @default.
• W3097279097 date "2021-01-01" @default.
• W3097279097 modified "2023-10-16" @default.
• W3097279097 title "The progression of pulmonary arterial hypertension induced by monocrotaline is characterized by lung nitrosative and oxidative stress, and impaired pulmonary artery reactivity" @default.
• W3097279097 cites W127541880 @default.
• W3097279097 cites W1546592314 @default.
• W3097279097 cites W1590457525 @default.
• W3097279097 cites W1755496226 @default.
• W3097279097 cites W1775749144 @default.
• W3097279097 cites W1821918060 @default.
• W3097279097 cites W1874170221 @default.
• W3097279097 cites W1893639916 @default.
• W3097279097 cites W191793640 @default.
• W3097279097 cites W1974061109 @default.
• W3097279097 cites W1974273092 @default.
• W3097279097 cites W1981280004 @default.
• W3097279097 cites W1996272751 @default.
• W3097279097 cites W1999649376 @default.
• W3097279097 cites W2002493975 @default.
• W3097279097 cites W2006370393 @default.
• W3097279097 cites W2009011266 @default.
• W3097279097 cites W2033781762 @default.
• W3097279097 cites W2039879879 @default.
• W3097279097 cites W2046875912 @default.
• W3097279097 cites W2047774204 @default.
• W3097279097 cites W2057810394 @default.
• W3097279097 cites W2061715434 @default.
• W3097279097 cites W2069248844 @default.
• W3097279097 cites W2073996953 @default.
• W3097279097 cites W2078069441 @default.
• W3097279097 cites W2088866343 @default.
• W3097279097 cites W2093943199 @default.
• W3097279097 cites W2100837269 @default.
• W3097279097 cites W2111420319 @default.
• W3097279097 cites W2115605234 @default.
• W3097279097 cites W2124105006 @default.
• W3097279097 cites W2124598461 @default.
• W3097279097 cites W2129513537 @default.
• W3097279097 cites W2133936093 @default.
• W3097279097 cites W2135788465 @default.
• W3097279097 cites W2136327118 @default.
• W3097279097 cites W2145816101 @default.
• W3097279097 cites W2162913476 @default.
• W3097279097 cites W2166811364 @default.
• W3097279097 cites W2170194742 @default.
• W3097279097 cites W2462870965 @default.
• W3097279097 cites W2512370137 @default.
• W3097279097 cites W2587066556 @default.
• W3097279097 cites W2611600800 @default.
• W3097279097 cites W2726316859 @default.
• W3097279097 cites W2754647604 @default.
• W3097279097 cites W2790488280 @default.
• W3097279097 cites W2790504833 @default.
• W3097279097 cites W2809566874 @default.
• W3097279097 cites W2884830729 @default.
• W3097279097 cites W2974971559 @default.
• W3097279097 cites W2977114598 @default.
• W3097279097 cites W3006941349 @default.
• W3097279097 cites W95460493 @default.
• W3097279097 doi "https://doi.org/10.1016/j.ejphar.2020.173699" @default.
• W3097279097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33160936" @default.
• W3097279097 hasPublicationYear "2021" @default.
• W3097279097 type Work @default.
• W3097279097 sameAs 3097279097 @default.
• W3097279097 citedByCount "15" @default.
• W3097279097 countsByYear W30972790972021 @default.
• W3097279097 countsByYear W30972790972022 @default.
• W3097279097 countsByYear W30972790972023 @default.
• W3097279097 crossrefType "journal-article" @default.
• W3097279097 hasAuthorship W3097279097A5007836955 @default.
• W3097279097 hasAuthorship W3097279097A5023193135 @default.
• W3097279097 hasAuthorship W3097279097A5030209314 @default.
• W3097279097 hasAuthorship W3097279097A5031009446 @default.
• W3097279097 hasAuthorship W3097279097A5037405233 @default.
• W3097279097 hasAuthorship W3097279097A5044815211 @default.
• W3097279097 hasAuthorship W3097279097A5046929223 @default.
• W3097279097 hasAuthorship W3097279097A5055347418 @default.
• W3097279097 hasAuthorship W3097279097A5078183327 @default.
• W3097279097 hasAuthorship W3097279097A5080083870 @default.
• W3097279097 hasAuthorship W3097279097A5084149872 @default.
• W3097279097 hasAuthorship W3097279097A5089277835 @default.
• W3097279097 hasAuthorship W3097279097A5090516833 @default.
• W3097279097 hasConcept C126322002 @default.
• W3097279097 hasConcept C134018914 @default.

• next