FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3097339993> ?p ?o ?g. }

• W3097339993 abstract "Abstract Background Severe COVID-19 is characterized by clinical and biological manifestations typically observed in sepsis. SARS-CoV-2 RNA is commonly detected in nasopharyngeal swabs, however viral RNA can be found also in peripheral blood and other tissues. Whether systemic spreading of the virus or viral components plays a role in the pathogenesis of the sepsis-like disease observed in severe COVID-19 is currently unknown. Methods We determined the association of plasma SARS-CoV-2 RNA with the biological responses and the clinical severity of patients with COVID-19. 250 patients with confirmed COVID-19 infection were recruited (50 outpatients, 100 hospitalised ward patients, and 100 critically ill). The association between plasma SARS-CoV-2 RNA and laboratory parameters was evaluated using multivariate GLM with a gamma distribution. The association between plasma SARS-CoV-2 RNA and severity was evaluated using multivariate ordinal logistic regression analysis and Generalized Linear Model (GLM) analysis with a binomial distribution. Results The presence of SARS-CoV-2-RNA viremia was independently associated with a number of features consistently identified in sepsis: 1) high levels of cytokines (including CXCL10, CCL-2, IL-10, IL-1ra, IL-15, and G-CSF); 2) higher levels of ferritin and LDH; 3) low lymphocyte and monocyte counts 4) and low platelet counts. In hospitalised patients, the presence of SARS-CoV-2-RNA viremia was independently associated with critical illness: (adjusted OR= 8.30 [CI95%=4.21 - 16.34], p < 0.001). CXCL10 was the most accurate identifier of SARS-CoV-2-RNA viremia in plasma (area under the curve (AUC), [CI95%], p) = 0.85 [0.80 - 0.89), <0.001]), suggesting its potential role as a surrogate biomarker of viremia. The cytokine IL-15 most accurately differentiated clinical ward patients from ICU patients (AUC: 0.82 [0.76 - 0.88], <0.001). Conclusions systemic dissemination of genomic material of SARS-CoV-2 is associated with a sepsis-like biological response and critical illness in patients with COVID-19. RNA viremia could represent an important link between SARS-CoV-2 infection, host response dysfunction and the transition from moderate illness to severe, sepsis-like COVID-19 disease." @default.
• W3097339993 created "2020-11-09" @default.
• W3097339993 creator A5001341164 @default.
• W3097339993 creator A5004482938 @default.
• W3097339993 creator A5004813391 @default.
• W3097339993 creator A5005358634 @default.
• W3097339993 creator A5005380031 @default.
• W3097339993 creator A5006925441 @default.
• W3097339993 creator A5007621420 @default.
• W3097339993 creator A5010039721 @default.
• W3097339993 creator A5011279712 @default.
• W3097339993 creator A5013672147 @default.
• W3097339993 creator A5014025889 @default.
• W3097339993 creator A5014766542 @default.
• W3097339993 creator A5014871619 @default.
• W3097339993 creator A5015867325 @default.
• W3097339993 creator A5017356920 @default.
• W3097339993 creator A5019236941 @default.
• W3097339993 creator A5020282852 @default.
• W3097339993 creator A5020868317 @default.
• W3097339993 creator A5022158519 @default.
• W3097339993 creator A5028257679 @default.
• W3097339993 creator A5028764873 @default.
• W3097339993 creator A5028889081 @default.
• W3097339993 creator A5033820862 @default.
• W3097339993 creator A5035226440 @default.
• W3097339993 creator A5036232543 @default.
• W3097339993 creator A5039340195 @default.
• W3097339993 creator A5041420584 @default.
• W3097339993 creator A5043842403 @default.
• W3097339993 creator A5045920567 @default.
• W3097339993 creator A5046990649 @default.
• W3097339993 creator A5047079943 @default.
• W3097339993 creator A5047985734 @default.
• W3097339993 creator A5048425573 @default.
• W3097339993 creator A5048600004 @default.
• W3097339993 creator A5050940546 @default.
• W3097339993 creator A5051642524 @default.
• W3097339993 creator A5055196299 @default.
• W3097339993 creator A5059808129 @default.
• W3097339993 creator A5060556552 @default.
• W3097339993 creator A5065219041 @default.
• W3097339993 creator A5065247962 @default.
• W3097339993 creator A5065286198 @default.
• W3097339993 creator A5068058423 @default.
• W3097339993 creator A5073121461 @default.
• W3097339993 creator A5073753580 @default.
• W3097339993 creator A5075123108 @default.
• W3097339993 creator A5075236355 @default.
• W3097339993 creator A5075448305 @default.
• W3097339993 creator A5075618417 @default.
• W3097339993 creator A5076022316 @default.
• W3097339993 creator A5076108608 @default.
• W3097339993 creator A5077617848 @default.
• W3097339993 creator A5078465507 @default.
• W3097339993 creator A5079019983 @default.
• W3097339993 creator A5081756028 @default.
• W3097339993 creator A5084266011 @default.
• W3097339993 creator A5085633122 @default.
• W3097339993 creator A5085894370 @default.
• W3097339993 creator A5086530602 @default.
• W3097339993 creator A5086997746 @default.
• W3097339993 creator A5089634270 @default.
• W3097339993 creator A5090465095 @default.
• W3097339993 creator A5091879977 @default.
• W3097339993 date "2020-08-31" @default.
• W3097339993 modified "2023-10-18" @default.
• W3097339993 title "SARS-CoV-2 RNA viremia is associated with a sepsis-like host response and critical illness in COVID-19" @default.
• W3097339993 cites W1898928487 @default.
• W3097339993 cites W2003474402 @default.
• W3097339993 cites W2046208657 @default.
• W3097339993 cites W2059426479 @default.
• W3097339993 cites W2076401107 @default.
• W3097339993 cites W2112139890 @default.
• W3097339993 cites W2112331687 @default.
• W3097339993 cites W2127774299 @default.
• W3097339993 cites W2189537077 @default.
• W3097339993 cites W2331968643 @default.
• W3097339993 cites W2589232255 @default.
• W3097339993 cites W2802009181 @default.
• W3097339993 cites W2895280037 @default.
• W3097339993 cites W2913143438 @default.
• W3097339993 cites W2980930900 @default.
• W3097339993 cites W2996830183 @default.
• W3097339993 cites W3005477624 @default.
• W3097339993 cites W3007460166 @default.
• W3097339993 cites W3012104520 @default.
• W3097339993 cites W3016538467 @default.
• W3097339993 cites W3016746341 @default.
• W3097339993 cites W3016771699 @default.
• W3097339993 cites W3022047971 @default.
• W3097339993 cites W3033153041 @default.
• W3097339993 cites W3033194401 @default.
• W3097339993 cites W3033683066 @default.
• W3097339993 cites W3034095150 @default.
• W3097339993 cites W3043979607 @default.
• W3097339993 cites W3044898763 @default.
• W3097339993 cites W3047686514 @default.
• W3097339993 cites W3048537770 @default.
• W3097339993 cites W3049622125 @default.

• next