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- W3097364124 abstract "Introduction: For non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations, tyrosine kinase inhibitors (TKIs) are the therapy of choice, with proved efficacy of osimertinib in case of progression with T790M exon 20 mutation. Real-world data regarding resistance profile with osimertinib remains limited. Methods: A retrospective analysis of T790M-mutated NSCLC patients, who initiated osimertinib between August 2016 and April 2019, was performed to investigate osimertinib´s resistance mechanism. Results: Twenty-one patients were included, 12(57.1%) female, mostly non-smokers (n=18; 85.7%), mean age 65.9±11.9 years, Exon 19 deletion in 17 (85%) . Objective response and disease control were 47.7% and 81%, respectively. Median progression-free survival of 14.7 months and overall survival of 29.6 months. Seven patients (33.3%) progressed. T790M mutation became undetectable in 3, with other molecular changes found in twoof them: MET amplification and PIK3CA mutation. In the T790M-persistent group, one case developed exon 20 C797S mutation, one DCTN1-ALK fusion transcript and one histological transformation in small cell carcinoma. Loss of T790M mutation was associated with earlier progression (7,7 vs 20,3 months, p=0,01). After progression, osimertinib was continued in 3 patients, 2 with local treatment. In 4 cases, a new therapy was started:chemotherapy (n=2); other TKI (n=2). Conclusion: Resistance mechanisms to osimertinib are diverse, therefore re-biopsy and Next Generation Sequencing are important to decide the subsequent strategy." @default.
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- W3097364124 date "2020-09-07" @default.
- W3097364124 modified "2023-09-26" @default.
- W3097364124 title "Progression after osimertinib in EGFR T790M-mutated non-small cell cancer patients" @default.
- W3097364124 doi "https://doi.org/10.1183/13993003.congress-2020.1694" @default.
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