FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3097366153> ?p ?o ?g. }

• W3097366153 endingPage "698" @default.
• W3097366153 startingPage "691" @default.
• W3097366153 abstract "Background and aims The oral administration of insulin has so far been precluded by gastro-intestinal enzyme degradation and poor intestinal absorption. Preliminary evidence for peptide uptake by the gut has recently been obtained, by our research group, following the administration of nanostructured lipid-carrier suspensions loaded with glargine insulin in healthy animal models. Methods and results In this experimental study, glargine insulin-loaded nanostructured lipid carriers have been converted into solid oral dosage forms (tablets, capsules), that are more suitable for administration in humans and have prolonged shelf-life. The liquid and solid oral dosage forms were tested for glargine insulin uptake and glucose responsivity in healthy and streptozotocin-induced diabetic rats (6 animals in each group). A suitable composition gave redispersible solid oral dosage forms from glargine insulin-loaded carriers, using both spray-drying and freeze-drying. It was observed that the liquid and solid formulations had relevant hypoglycaemic effects in healthy rats, while only capsules were efficacious in diabetic rats; probably because of gut alterations in these animal models. Detected glargine insulinaemia was consistent with a glycaemic profile. Conclusion The formulations under study showed their potential as oral glucose-lowering agents, particularly when used as capsules. However, further study is needed to produce a useful orally-active insulin preparation." @default.
• W3097366153 created "2020-11-09" @default.
• W3097366153 creator A5016393721 @default.
• W3097366153 creator A5030120650 @default.
• W3097366153 creator A5031331537 @default.
• W3097366153 creator A5035816396 @default.
• W3097366153 creator A5037074434 @default.
• W3097366153 creator A5044648942 @default.
• W3097366153 creator A5053899058 @default.
• W3097366153 creator A5057269575 @default.
• W3097366153 creator A5071628074 @default.
• W3097366153 creator A5091815659 @default.
• W3097366153 date "2021-02-01" @default.
• W3097366153 modified "2023-10-14" @default.
• W3097366153 title "Glargine insulin loaded lipid nanoparticles: Oral delivery of liquid and solid oral dosage forms" @default.
• W3097366153 cites W1563608944 @default.
• W3097366153 cites W1963930717 @default.
• W3097366153 cites W1967195599 @default.
• W3097366153 cites W2008065995 @default.
• W3097366153 cites W2017375426 @default.
• W3097366153 cites W2040812195 @default.
• W3097366153 cites W2042171162 @default.
• W3097366153 cites W2064452006 @default.
• W3097366153 cites W2093962452 @default.
• W3097366153 cites W2107223164 @default.
• W3097366153 cites W2114403974 @default.
• W3097366153 cites W2119304571 @default.
• W3097366153 cites W2120826143 @default.
• W3097366153 cites W2133839434 @default.
• W3097366153 cites W2147956742 @default.
• W3097366153 cites W2148994299 @default.
• W3097366153 cites W2575410421 @default.
• W3097366153 cites W2587225611 @default.
• W3097366153 cites W2750934760 @default.
• W3097366153 cites W2767172014 @default.
• W3097366153 cites W2856506235 @default.
• W3097366153 cites W2908705911 @default.
• W3097366153 cites W2945080898 @default.
• W3097366153 cites W2962397898 @default.
• W3097366153 cites W2968317635 @default.
• W3097366153 doi "https://doi.org/10.1016/j.numecd.2020.09.020" @default.
• W3097366153 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33131992" @default.
• W3097366153 hasPublicationYear "2021" @default.
• W3097366153 type Work @default.
• W3097366153 sameAs 3097366153 @default.
• W3097366153 citedByCount "7" @default.
• W3097366153 countsByYear W30973661532021 @default.
• W3097366153 countsByYear W30973661532022 @default.
• W3097366153 countsByYear W30973661532023 @default.
• W3097366153 crossrefType "journal-article" @default.
• W3097366153 hasAuthorship W3097366153A5016393721 @default.
• W3097366153 hasAuthorship W3097366153A5030120650 @default.
• W3097366153 hasAuthorship W3097366153A5031331537 @default.
• W3097366153 hasAuthorship W3097366153A5035816396 @default.
• W3097366153 hasAuthorship W3097366153A5037074434 @default.
• W3097366153 hasAuthorship W3097366153A5044648942 @default.
• W3097366153 hasAuthorship W3097366153A5053899058 @default.
• W3097366153 hasAuthorship W3097366153A5057269575 @default.
• W3097366153 hasAuthorship W3097366153A5071628074 @default.
• W3097366153 hasAuthorship W3097366153A5091815659 @default.
• W3097366153 hasConcept C126322002 @default.
• W3097366153 hasConcept C134018914 @default.
• W3097366153 hasConcept C199529486 @default.
• W3097366153 hasConcept C2777056448 @default.
• W3097366153 hasConcept C2779306644 @default.
• W3097366153 hasConcept C2779920387 @default.
• W3097366153 hasConcept C2780035454 @default.
• W3097366153 hasConcept C2780668416 @default.
• W3097366153 hasConcept C555293320 @default.
• W3097366153 hasConcept C71924100 @default.
• W3097366153 hasConcept C77281830 @default.
• W3097366153 hasConcept C98274493 @default.
• W3097366153 hasConceptScore W3097366153C126322002 @default.
• W3097366153 hasConceptScore W3097366153C134018914 @default.
• W3097366153 hasConceptScore W3097366153C199529486 @default.
• W3097366153 hasConceptScore W3097366153C2777056448 @default.
• W3097366153 hasConceptScore W3097366153C2779306644 @default.
• W3097366153 hasConceptScore W3097366153C2779920387 @default.
• W3097366153 hasConceptScore W3097366153C2780035454 @default.
• W3097366153 hasConceptScore W3097366153C2780668416 @default.
• W3097366153 hasConceptScore W3097366153C555293320 @default.
• W3097366153 hasConceptScore W3097366153C71924100 @default.
• W3097366153 hasConceptScore W3097366153C77281830 @default.
• W3097366153 hasConceptScore W3097366153C98274493 @default.
• W3097366153 hasFunder F4320324041 @default.
• W3097366153 hasIssue "2" @default.
• W3097366153 hasLocation W30973661531 @default.
• W3097366153 hasOpenAccess W3097366153 @default.
• W3097366153 hasPrimaryLocation W30973661531 @default.
• W3097366153 hasRelatedWork W1964829482 @default.
• W3097366153 hasRelatedWork W1969876219 @default.
• W3097366153 hasRelatedWork W2057459363 @default.
• W3097366153 hasRelatedWork W2393371520 @default.
• W3097366153 hasRelatedWork W2596397503 @default.
• W3097366153 hasRelatedWork W2794331367 @default.
• W3097366153 hasRelatedWork W2809998795 @default.
• W3097366153 hasRelatedWork W3097366153 @default.
• W3097366153 hasRelatedWork W2479984731 @default.

• next