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• W3097371189 abstract "Abstract Hepatitis E has emerged as a major transfusion-transmitted infectious risk. Two recipients of plasma from 2 lots (A and B) of pooled solvent/detergent–treated plasma were found to be infected by hepatitis E virus (HEV) that was determined to have been transmitted by the solvent/detergent–treated plasma. HEV RNA viral loads were 433 IU in lot A and 55 IU in lot B. Retrospective studies found that 100% (13/13) of evaluable lot A recipients versus 18% (3/17) of evaluable lot B recipients had been infected by HEV (p<0.001), albeit not necessarily at time of transfusion. Among evaluable recipients, 86% with a transfused HEV RNA load >50,000 IU were infected, most likely by the HEV-containing solvent/detergent–treated plasma, versus only 7% with a transfused HEV RNA load <50,000 IU (p<0.001). Overall, solvent/detergent–treated plasma might harbor HEV. Such an occurrence might result in a dose-dependent risk for transfusion-transmitted hepatitis E." @default.
• W3097371189 created "2020-11-09" @default.
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• W3097371189 date "2020-12-01" @default.
• W3097371189 modified "2023-10-16" @default.
• W3097371189 title "Risk for Hepatitis E Virus Transmission by Solvent/Detergent–Treated Plasma" @default.
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• W3097371189 doi "https://doi.org/10.3201/eid2612.191482" @default.
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