Matches in SemOpenAlex for { <https://semopenalex.org/work/W3097427958> ?p ?o ?g. }
- W3097427958 endingPage "1536" @default.
- W3097427958 startingPage "1526" @default.
- W3097427958 abstract "Gamma knife radiosurgery is regarded as the gold-standard stereotactic radiosurgery modality for the treatment of intracranial tumours, and its use has been expanded for the treatment of intraocular malignancies. The aim of this study was to systematically evaluate the efficacy, outcomes, and complications of gamma knife radiosurgery for uveal melanomas and metastases.We did a systematic review and meta-analysis to aggregate the clinical outcomes of patients with uveal melanomas or intraocular metastases treated primarily with gamma knife radiosurgery. We searched MEDLINE and Embase for studies published between Sept 1, 1960, and Feb 1, 2020, reporting the use of gamma knife radiosurgery as primary treatment for uveal melanoma or uveal metastases. The search was restricted to clinical studies and relevant grey literature published in English. Studies reporting treatment of benign tumours, extraocular tumours, or other forms of stereotactic radiosurgery were excluded to reduce heterogeneity. No restrictions were placed on participant criteria. Local tumour control and tumour regression were extracted as the primary outcomes and analysed via a random-effects meta-analysis of proportions using the DerSimonian and Laird method with a Freeman-Tukey double arcsine transformation. This study is registered with PROSPERO, CRD42019148165.Our search returned 454 studies, of which 109 were assessed for full-text eligibility. 52 studies, reporting on 1010 patients with uveal melanoma and 34 intraocular metastases, were eligible for systematic review. 28 studies were included in the meta-analysis. 840 of 898 patients (0·96, 95% CI 0·94-0·97; I2=16%) from 19 studies had local control, and 378 of 478 patients (0·81, 0·70-0·90; I2=83%) from 16 studies experienced tumour regression.Gamma knife radiosurgery is an efficacious primary method of treating uveal melanomas and intraocular metastases, with reliable tumour control rates. Randomised controlled trials should further evaluate the safety and efficacy of gamma knife radiosurgery in this setting.The Rhodes Trust and the Howard Brain Sciences Foundation." @default.
- W3097427958 created "2020-11-09" @default.
- W3097427958 creator A5005837970 @default.
- W3097427958 creator A5011427447 @default.
- W3097427958 creator A5018134307 @default.
- W3097427958 creator A5046710112 @default.
- W3097427958 creator A5048305319 @default.
- W3097427958 creator A5054386358 @default.
- W3097427958 creator A5059544195 @default.
- W3097427958 creator A5071828351 @default.
- W3097427958 creator A5073459233 @default.
- W3097427958 creator A5082744383 @default.
- W3097427958 date "2020-11-01" @default.
- W3097427958 modified "2023-10-16" @default.
- W3097427958 title "Gamma knife radiosurgery for uveal melanomas and metastases: a systematic review and meta-analysis" @default.
- W3097427958 cites W1488405673 @default.
- W3097427958 cites W1577481766 @default.
- W3097427958 cites W1958385404 @default.
- W3097427958 cites W1976093337 @default.
- W3097427958 cites W1995835953 @default.
- W3097427958 cites W2006127570 @default.
- W3097427958 cites W2012636425 @default.
- W3097427958 cites W2022516369 @default.
- W3097427958 cites W2022704949 @default.
- W3097427958 cites W2022921829 @default.
- W3097427958 cites W2026106961 @default.
- W3097427958 cites W2027879900 @default.
- W3097427958 cites W2044112280 @default.
- W3097427958 cites W2047244283 @default.
- W3097427958 cites W2048258526 @default.
- W3097427958 cites W2054545149 @default.
- W3097427958 cites W2056453159 @default.
- W3097427958 cites W2057801728 @default.
- W3097427958 cites W2061703465 @default.
- W3097427958 cites W2062242147 @default.
- W3097427958 cites W2062547098 @default.
- W3097427958 cites W2066348781 @default.
- W3097427958 cites W2068251663 @default.
- W3097427958 cites W2069011324 @default.
- W3097427958 cites W2069277297 @default.
- W3097427958 cites W2075478251 @default.
- W3097427958 cites W2076305655 @default.
- W3097427958 cites W2078961502 @default.
- W3097427958 cites W2082625811 @default.
- W3097427958 cites W2092522736 @default.
- W3097427958 cites W2097117666 @default.
- W3097427958 cites W2110994244 @default.
- W3097427958 cites W2119860530 @default.
- W3097427958 cites W2122012724 @default.
- W3097427958 cites W2123579038 @default.
- W3097427958 cites W2130790436 @default.
- W3097427958 cites W2137096329 @default.
- W3097427958 cites W2141190166 @default.
- W3097427958 cites W2145253282 @default.
- W3097427958 cites W2156098321 @default.
- W3097427958 cites W2158931777 @default.
- W3097427958 cites W2237941704 @default.
- W3097427958 cites W2277371348 @default.
- W3097427958 cites W2284940273 @default.
- W3097427958 cites W2316359939 @default.
- W3097427958 cites W2323144468 @default.
- W3097427958 cites W2327148861 @default.
- W3097427958 cites W2508646235 @default.
- W3097427958 cites W2517207406 @default.
- W3097427958 cites W2555045550 @default.
- W3097427958 cites W2559127842 @default.
- W3097427958 cites W2562156357 @default.
- W3097427958 cites W2587272483 @default.
- W3097427958 cites W2588351038 @default.
- W3097427958 cites W2598330493 @default.
- W3097427958 cites W2756316045 @default.
- W3097427958 cites W2765160075 @default.
- W3097427958 cites W2777581894 @default.
- W3097427958 cites W2946958141 @default.
- W3097427958 cites W2972191720 @default.
- W3097427958 cites W2991792334 @default.
- W3097427958 cites W4232933701 @default.
- W3097427958 cites W4239509499 @default.
- W3097427958 cites W4242987572 @default.
- W3097427958 cites W4253975669 @default.
- W3097427958 cites W4254282631 @default.
- W3097427958 cites W4360790358 @default.
- W3097427958 cites W755887531 @default.
- W3097427958 cites W1966365632 @default.
- W3097427958 doi "https://doi.org/10.1016/s1470-2045(20)30459-9" @default.
- W3097427958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33152286" @default.
- W3097427958 hasPublicationYear "2020" @default.
- W3097427958 type Work @default.
- W3097427958 sameAs 3097427958 @default.
- W3097427958 citedByCount "18" @default.
- W3097427958 countsByYear W30974279582021 @default.
- W3097427958 countsByYear W30974279582022 @default.
- W3097427958 countsByYear W30974279582023 @default.
- W3097427958 crossrefType "journal-article" @default.
- W3097427958 hasAuthorship W3097427958A5005837970 @default.
- W3097427958 hasAuthorship W3097427958A5011427447 @default.
- W3097427958 hasAuthorship W3097427958A5018134307 @default.
- W3097427958 hasAuthorship W3097427958A5046710112 @default.