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- W3097432868 abstract "Protracted bacterial bronchitis (PBB) is the relatively new clinical nosology in children. PBB is characterized by an isolated chronic (lasting > 4 weeks) wet or productive cough without signs of another cause, and usually responds to 2 weeks of an appropriate oral antibiotic. Untreated PBB with ongoing bacterial infection would lead to chronic airway inflammation and bronchiectasis. The aim is to study the clinical and microbiological features of PBB in children and to determine the risk factors for chronic bronchitis (СВ) development. Methods of research: 21 children with PBB (average age – 3.8±0.6 years) and 41 children with CB (average age – 14.7±2.6 years) were examined. The study included the collection of anamnesis, chest X-ray, bronchoscopy and microbiological examination. Results: The total duration of PBB was 4.1±0.3 weeks, in children with CB the experience of the disease was 6.2±1.1 years, the annual duration of cough was 2.2±0.2 months. Bronchiectasis were found in 36.5% of children with CB. Bronchoscopy revealed mostly catarrhal-purulent (58.5 %) endobronchitis, the atrophy signs of the mucous membrane (34.1%) and dysplasia of bronchial epithelial (46.3%) in children with CB. The most frequent cause of the disease in children with РBB was Str. pneumonia (52.4%), in children with СВ exacerbation - H. influenzae (65.2%). Aerococcus viridans, as a representative of the normal bronchial microbiome, was identified in 81.0% patients with PBB and in 8.7% with CB. Conclusion: The risk factors for СВ development in children with PBВ are the lower respiratory tract H. influenzae colonization and decreased activity or absence of Aerococcus viridans." @default.
- W3097432868 created "2020-11-09" @default.
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- W3097432868 date "2020-09-07" @default.
- W3097432868 modified "2023-10-16" @default.
- W3097432868 title "The clinical and microbiological features of PBB in children and the risk factors for chronic bronchitis development" @default.
- W3097432868 doi "https://doi.org/10.1183/13993003.congress-2020.1159" @default.
- W3097432868 hasPublicationYear "2020" @default.
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