Matches in SemOpenAlex for { <https://semopenalex.org/work/W3097432941> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W3097432941 endingPage "114307" @default.
- W3097432941 startingPage "114307" @default.
- W3097432941 abstract "Patch clamp investigations of single ion channels give insight into the function of these proteins on the molecular level. Utilizing this technique, we performed detailed investigations of the human P2X7 receptor, which is a ligand gated ion channel opened by binding of ATP, like the other P2X receptor subtypes. P2X7 receptors become activated under pathological conditions of ATP release like hypoxia or cell destruction. They are involved in inflammatory and nociceptive reactions of the organism to these pathological events. Knowledge about the function of the P2X7 receptor might lead to a deeper insight into the signaling within these pathophysiological processes and to reveal targets of anti-inflammatory and anti-nociceptive therapies. We found that hP2X7 receptors become activated by ATP within a few milliseconds and are permeable only to cations. Their ion channel conductance remains constant across minutes of activation, which argues against dilation of the ion channel pore. Substitution of Na+ or Cl− ions not only influences the ion channel current amplitude but also the channel gating. Polar residues of the second transmembrane domains of the three protein subunits are important for ion conduction, with S342 constituting the ion selectivity filter and the gate of the channel. The specific long C-terminal domains are important for hP2X7 receptor ion channel function, as their loss strongly decreases ion channel currents." @default.
- W3097432941 created "2020-11-09" @default.
- W3097432941 creator A5014665429 @default.
- W3097432941 date "2021-05-01" @default.
- W3097432941 modified "2023-10-01" @default.
- W3097432941 title "Human P2X7 receptors – Properties of single ATP-gated ion channels" @default.
- W3097432941 cites W1970613983 @default.
- W3097432941 cites W1975218336 @default.
- W3097432941 cites W1977138796 @default.
- W3097432941 cites W1998127230 @default.
- W3097432941 cites W2001841630 @default.
- W3097432941 cites W2004066544 @default.
- W3097432941 cites W2007318811 @default.
- W3097432941 cites W2040783182 @default.
- W3097432941 cites W2052546808 @default.
- W3097432941 cites W2066784771 @default.
- W3097432941 cites W2068517470 @default.
- W3097432941 cites W2076830327 @default.
- W3097432941 cites W2099163813 @default.
- W3097432941 cites W2101573249 @default.
- W3097432941 cites W2113903630 @default.
- W3097432941 cites W2136134177 @default.
- W3097432941 cites W2589390874 @default.
- W3097432941 cites W2787249947 @default.
- W3097432941 cites W2960793673 @default.
- W3097432941 doi "https://doi.org/10.1016/j.bcp.2020.114307" @default.
- W3097432941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33130127" @default.
- W3097432941 hasPublicationYear "2021" @default.
- W3097432941 type Work @default.
- W3097432941 sameAs 3097432941 @default.
- W3097432941 citedByCount "9" @default.
- W3097432941 countsByYear W30974329412021 @default.
- W3097432941 countsByYear W30974329412022 @default.
- W3097432941 countsByYear W30974329412023 @default.
- W3097432941 crossrefType "journal-article" @default.
- W3097432941 hasAuthorship W3097432941A5014665429 @default.
- W3097432941 hasConcept C12554922 @default.
- W3097432941 hasConcept C167007842 @default.
- W3097432941 hasConcept C170493617 @default.
- W3097432941 hasConcept C181911157 @default.
- W3097432941 hasConcept C185592680 @default.
- W3097432941 hasConcept C194544171 @default.
- W3097432941 hasConcept C37088560 @default.
- W3097432941 hasConcept C50254741 @default.
- W3097432941 hasConcept C53465041 @default.
- W3097432941 hasConcept C55493867 @default.
- W3097432941 hasConcept C82617044 @default.
- W3097432941 hasConcept C86803240 @default.
- W3097432941 hasConcept C95444343 @default.
- W3097432941 hasConceptScore W3097432941C12554922 @default.
- W3097432941 hasConceptScore W3097432941C167007842 @default.
- W3097432941 hasConceptScore W3097432941C170493617 @default.
- W3097432941 hasConceptScore W3097432941C181911157 @default.
- W3097432941 hasConceptScore W3097432941C185592680 @default.
- W3097432941 hasConceptScore W3097432941C194544171 @default.
- W3097432941 hasConceptScore W3097432941C37088560 @default.
- W3097432941 hasConceptScore W3097432941C50254741 @default.
- W3097432941 hasConceptScore W3097432941C53465041 @default.
- W3097432941 hasConceptScore W3097432941C55493867 @default.
- W3097432941 hasConceptScore W3097432941C82617044 @default.
- W3097432941 hasConceptScore W3097432941C86803240 @default.
- W3097432941 hasConceptScore W3097432941C95444343 @default.
- W3097432941 hasFunder F4320320879 @default.
- W3097432941 hasLocation W30974329411 @default.
- W3097432941 hasOpenAccess W3097432941 @default.
- W3097432941 hasPrimaryLocation W30974329411 @default.
- W3097432941 hasRelatedWork W1968920700 @default.
- W3097432941 hasRelatedWork W2005242686 @default.
- W3097432941 hasRelatedWork W2029357738 @default.
- W3097432941 hasRelatedWork W2033259519 @default.
- W3097432941 hasRelatedWork W2124669621 @default.
- W3097432941 hasRelatedWork W2269463474 @default.
- W3097432941 hasRelatedWork W2279398309 @default.
- W3097432941 hasRelatedWork W3023541640 @default.
- W3097432941 hasRelatedWork W3097432941 @default.
- W3097432941 hasRelatedWork W4211085230 @default.
- W3097432941 hasVolume "187" @default.
- W3097432941 isParatext "false" @default.
- W3097432941 isRetracted "false" @default.
- W3097432941 magId "3097432941" @default.
- W3097432941 workType "article" @default.