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• W3097434490 abstract "In vitro 3D culture systems provide promising tools for screening novel therapies and understanding drug resistance mechanisms in cancer because they are adapted for high throughput analysis. One of the main current challenges is to reproducibly culture patient samples containing cancer and stromal cells to faithfully recapitulate tumor microenvironment and move towards efficient personalized medicine. Tumors are composed of heterogeneous cell populations and characterized by chaotic vascularization in a remodeled microenvironment. Indeed, tumor angiogenesis occurs in a complex stroma containing immune cells and cancer-associated fibroblasts that secrete important amounts of cytokines, growth factors, microvesicles and ECM. This process leads to the formation of inflated, tortuous and permeable capillaries that display deficient basement membrane and perivascular coverage. These abnormal capillaries affect responses to anti-cancer therapies such as anti-angiogenic, radio- and immunotherapies. Current pre-clinical models are limited for investigating interactions between tumor cells and vascularization during tumor progression as well as mechanisms that lead to drug resistance. In vitro approaches developed for vascularization are either the result of engineered cell lining or based on physiological processes including vasculogenesis and sprouting angiogenesis. They allow investigation of paracrine and direct interactions between EC and tumor and/or stromal cells, as well as impact of biochemical and biophysical cues of the microenvironment, using either natural matrix components or functionalized synthetic hydrogels. In addition, microfluidic devices provide access to modeling the impact of shear stress and interstitial flow and growth factor gradients. In this review, we will describe the state of the art co-culture models of vascularized micro-tumors in order to study tumor progression and metastatic dissemination including intravasation and/or extravasation processes." @default.
• W3097434490 created "2020-11-09" @default.
• W3097434490 creator A5000781991 @default.
• W3097434490 creator A5002524980 @default.
• W3097434490 creator A5007193297 @default.
• W3097434490 creator A5087416823 @default.
• W3097434490 date "2020-11-05" @default.
• W3097434490 modified "2023-10-18" @default.
• W3097434490 title "In vitro 3D Systems to Model Tumor Angiogenesis and Interactions With Stromal Cells" @default.
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