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- W3097434562 endingPage "8205" @default.
- W3097434562 startingPage "8205" @default.
- W3097434562 abstract "Space exploration poses multiple challenges for mankind, not only on a technical level but also to the entire physiology of the space traveller. The human system must adapt to several environmental stressors, microgravity being one of them. Lysosomes are ubiquitous to every cell and essential for their homeostasis, playing significant roles in the regulation of autophagy, immunity, and adaptation of the organism to changes in their environment, to name a few. Dysfunction of the lysosomal system leads to age-related diseases, for example bone loss, reduced immune response or cancer. As these conditions have been shown to be accelerated following exposure to microgravity, this review elucidates the lysosomal response to real and simulated microgravity. Microgravity activates the endo-lysosomal system, with resulting impacts on bone loss, muscle atrophy and stem cell differentiation. The investigation of lysosomal adaptation to microgravity can be beneficial in the search for new biomarkers or therapeutic approaches to several disease pathologies on earth as well as the potential to mitigate pathophysiology during spaceflight." @default.
- W3097434562 created "2020-11-09" @default.
- W3097434562 creator A5025604043 @default.
- W3097434562 creator A5027579282 @default.
- W3097434562 creator A5041493693 @default.
- W3097434562 creator A5082120013 @default.
- W3097434562 date "2020-11-02" @default.
- W3097434562 modified "2023-10-14" @default.
- W3097434562 title "Implications of Altered Endosome and Lysosome Biology in Space Environments" @default.
- W3097434562 cites W1179548401 @default.
- W3097434562 cites W1495021455 @default.
- W3097434562 cites W1502613487 @default.
- W3097434562 cites W1524656751 @default.
- W3097434562 cites W1543344223 @default.
- W3097434562 cites W1558821075 @default.
- W3097434562 cites W1606604744 @default.
- W3097434562 cites W1625997318 @default.
- W3097434562 cites W1764537400 @default.
- W3097434562 cites W1860190162 @default.
- W3097434562 cites W19332027 @default.
- W3097434562 cites W1933877372 @default.
- W3097434562 cites W1947259556 @default.
- W3097434562 cites W1967502057 @default.
- W3097434562 cites W1968773749 @default.
- W3097434562 cites W1971349835 @default.
- W3097434562 cites W1975733191 @default.
- W3097434562 cites W1986214667 @default.
- W3097434562 cites W1990392228 @default.
- W3097434562 cites W1992401482 @default.
- W3097434562 cites W1994163197 @default.
- W3097434562 cites W1994174491 @default.
- W3097434562 cites W1998083136 @default.
- W3097434562 cites W2000313603 @default.
- W3097434562 cites W2000791145 @default.
- W3097434562 cites W2005517963 @default.
- W3097434562 cites W2013908114 @default.
- W3097434562 cites W2014078285 @default.
- W3097434562 cites W2014833779 @default.
- W3097434562 cites W2016468663 @default.
- W3097434562 cites W2017969831 @default.
- W3097434562 cites W2028276122 @default.
- W3097434562 cites W2033242249 @default.
- W3097434562 cites W2039509275 @default.
- W3097434562 cites W2043304304 @default.
- W3097434562 cites W2054594032 @default.
- W3097434562 cites W2059050560 @default.
- W3097434562 cites W2059133755 @default.
- W3097434562 cites W2060031713 @default.
- W3097434562 cites W2066071775 @default.
- W3097434562 cites W2070143299 @default.
- W3097434562 cites W2073285975 @default.
- W3097434562 cites W2077499130 @default.
- W3097434562 cites W2077559627 @default.
- W3097434562 cites W2078391920 @default.
- W3097434562 cites W2078536317 @default.
- W3097434562 cites W2080815560 @default.
- W3097434562 cites W2081263377 @default.
- W3097434562 cites W2083991002 @default.
- W3097434562 cites W2087560312 @default.
- W3097434562 cites W2088951509 @default.
- W3097434562 cites W2089997538 @default.
- W3097434562 cites W2090224335 @default.
- W3097434562 cites W2092875599 @default.
- W3097434562 cites W2095857644 @default.
- W3097434562 cites W2099304566 @default.
- W3097434562 cites W2105114667 @default.
- W3097434562 cites W2112110295 @default.
- W3097434562 cites W2113766700 @default.
- W3097434562 cites W2115346271 @default.
- W3097434562 cites W2122322149 @default.
- W3097434562 cites W2122556106 @default.
- W3097434562 cites W2127839969 @default.
- W3097434562 cites W2128520952 @default.
- W3097434562 cites W2128677681 @default.
- W3097434562 cites W2130053803 @default.
- W3097434562 cites W2137857464 @default.
- W3097434562 cites W2144293442 @default.
- W3097434562 cites W2145822917 @default.
- W3097434562 cites W2145956680 @default.
- W3097434562 cites W2146316921 @default.
- W3097434562 cites W2149193631 @default.
- W3097434562 cites W2156204535 @default.
- W3097434562 cites W2159321716 @default.
- W3097434562 cites W2159362168 @default.
- W3097434562 cites W2159796957 @default.
- W3097434562 cites W2171016021 @default.
- W3097434562 cites W2181494902 @default.
- W3097434562 cites W2221707331 @default.
- W3097434562 cites W2230472805 @default.
- W3097434562 cites W2234818479 @default.
- W3097434562 cites W2287987188 @default.
- W3097434562 cites W2326068206 @default.
- W3097434562 cites W2327026285 @default.
- W3097434562 cites W2344789131 @default.
- W3097434562 cites W2411692865 @default.
- W3097434562 cites W2413359989 @default.
- W3097434562 cites W2415922856 @default.
- W3097434562 cites W2416414475 @default.