Matches in SemOpenAlex for { <https://semopenalex.org/work/W3097477033> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W3097477033 abstract "Fetal growth is a complex, dynamic process controlled by a wide range of maternal, placental and fetal influences. As a result, the aetiology of intrauterine growth restriction (IUGR) is often multifactorial, involving both genetic and environmental factors. In early fetal life, the major determinant of growth is the fetal genome, but later in pregnancy, environment, nutrition and hormonal factors become increasingly important. In this study, we have assessed the involvement of genomic imprinting, specifically of genes mapping to the human chromosome 6-imprinted domain. Genomic imprinting is an epigenetic mechanism of regulation that results in parent-of-origin expression. It is an important regulatory pathway involved in the development and function of the placenta. Presently, genomic imprinting is understood to be a mechanism aimed at controlling the amount of maternal resources allocated to the offspring from conception to weaning. The human chromosome 6-imprinted domain contains the paternally expressed ZAC1/PLAGL1 gene. Loss-of-imprinting of ZAC1/PLAGL1 in humans leads to IUGR and transient neonatal diabetes mellitus. Intriguingly loss of expression in mouse models also results in IUGR, suggesting that aberrant fluctuation of ZAC expression influences a network that regulates fetal growth. To characterize the extent of this imprinted domain, we have assessed the parent-of-origin expression for 10 additional genes mapping to this interval. In addition, to gain insights into the physiological relevance of ZAC1/PLAGL1 in normal growth, we have assessed the expression levels of the various ZAC isoforms and the DNA methylation profile of the ZAC1/HYMAI promoter in a cohort of 120 consecutively collected placenta samples." @default.
- W3097477033 created "2020-11-09" @default.
- W3097477033 creator A5018199257 @default.
- W3097477033 creator A5028228166 @default.
- W3097477033 creator A5039837099 @default.
- W3097477033 creator A5054323862 @default.
- W3097477033 creator A5054954029 @default.
- W3097477033 creator A5074270031 @default.
- W3097477033 date "2008-11-01" @default.
- W3097477033 modified "2023-10-13" @default.
- W3097477033 title "ANALYSIS OF THE IMPRINTED GENE ZAC1 AND THE 6Q24-Q25 REGION IN FETAL GROWTH" @default.
- W3097477033 hasPublicationYear "2008" @default.
- W3097477033 type Work @default.
- W3097477033 sameAs 3097477033 @default.
- W3097477033 citedByCount "0" @default.
- W3097477033 crossrefType "journal-article" @default.
- W3097477033 hasAuthorship W3097477033A5018199257 @default.
- W3097477033 hasAuthorship W3097477033A5028228166 @default.
- W3097477033 hasAuthorship W3097477033A5039837099 @default.
- W3097477033 hasAuthorship W3097477033A5054323862 @default.
- W3097477033 hasAuthorship W3097477033A5054954029 @default.
- W3097477033 hasAuthorship W3097477033A5074270031 @default.
- W3097477033 hasConcept C104317684 @default.
- W3097477033 hasConcept C112672928 @default.
- W3097477033 hasConcept C150194340 @default.
- W3097477033 hasConcept C165864922 @default.
- W3097477033 hasConcept C172680121 @default.
- W3097477033 hasConcept C190727270 @default.
- W3097477033 hasConcept C201492766 @default.
- W3097477033 hasConcept C2776953305 @default.
- W3097477033 hasConcept C2778780700 @default.
- W3097477033 hasConcept C2779234561 @default.
- W3097477033 hasConcept C41091548 @default.
- W3097477033 hasConcept C54355233 @default.
- W3097477033 hasConcept C86803240 @default.
- W3097477033 hasConcept C94715292 @default.
- W3097477033 hasConceptScore W3097477033C104317684 @default.
- W3097477033 hasConceptScore W3097477033C112672928 @default.
- W3097477033 hasConceptScore W3097477033C150194340 @default.
- W3097477033 hasConceptScore W3097477033C165864922 @default.
- W3097477033 hasConceptScore W3097477033C172680121 @default.
- W3097477033 hasConceptScore W3097477033C190727270 @default.
- W3097477033 hasConceptScore W3097477033C201492766 @default.
- W3097477033 hasConceptScore W3097477033C2776953305 @default.
- W3097477033 hasConceptScore W3097477033C2778780700 @default.
- W3097477033 hasConceptScore W3097477033C2779234561 @default.
- W3097477033 hasConceptScore W3097477033C41091548 @default.
- W3097477033 hasConceptScore W3097477033C54355233 @default.
- W3097477033 hasConceptScore W3097477033C86803240 @default.
- W3097477033 hasConceptScore W3097477033C94715292 @default.
- W3097477033 hasLocation W30974770331 @default.
- W3097477033 hasOpenAccess W3097477033 @default.
- W3097477033 hasPrimaryLocation W30974770331 @default.
- W3097477033 hasRelatedWork W1678453733 @default.
- W3097477033 hasRelatedWork W1969172377 @default.
- W3097477033 hasRelatedWork W1990552468 @default.
- W3097477033 hasRelatedWork W2019362605 @default.
- W3097477033 hasRelatedWork W2026274018 @default.
- W3097477033 hasRelatedWork W2027302112 @default.
- W3097477033 hasRelatedWork W2046097091 @default.
- W3097477033 hasRelatedWork W2063705083 @default.
- W3097477033 hasRelatedWork W2064702709 @default.
- W3097477033 hasRelatedWork W2092612158 @default.
- W3097477033 hasRelatedWork W2115956830 @default.
- W3097477033 hasRelatedWork W2116734905 @default.
- W3097477033 hasRelatedWork W2122008685 @default.
- W3097477033 hasRelatedWork W2141298577 @default.
- W3097477033 hasRelatedWork W2156880397 @default.
- W3097477033 hasRelatedWork W2488177608 @default.
- W3097477033 hasRelatedWork W2768352326 @default.
- W3097477033 hasRelatedWork W2768805139 @default.
- W3097477033 hasRelatedWork W597303688 @default.
- W3097477033 hasRelatedWork W617743055 @default.
- W3097477033 hasVolume "93" @default.
- W3097477033 isParatext "false" @default.
- W3097477033 isRetracted "false" @default.
- W3097477033 magId "3097477033" @default.
- W3097477033 workType "article" @default.