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- W3097478077 abstract "Almost ten years have elapsed from the pivotal studies that established the RANK ligand denosumab in the forefront of bone-targeted agents (BTAs) for the prevention of skeletal-related events (SREs) [1–3]. In a landscape of established use of both denosumab and bisphosphonates for the management of patients with bone metastases from solid tumours, we have still not found the optimal schedule for their use in terms of risk-benefit ratio. As overall survival benefit has not been achieved by BTAs, it is important to maximise their utility in regard to SREs while minimising toxicity, notably osteonecrosis of the jaw and hypocalcaemia [4,5], and eventually reduce cost and treatment burden for patients." @default.
- W3097478077 created "2020-11-09" @default.
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- W3097478077 date "2021-01-01" @default.
- W3097478077 modified "2023-09-25" @default.
- W3097478077 title "Treading carefully in de-escalation for bone-targeted agents – is less more, after all?" @default.
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- W3097478077 doi "https://doi.org/10.1016/j.ejca.2020.09.019" @default.
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