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• W3097484053 abstract "Background: Blood biomarkers may enhance outcome prediction performance of head computed tomography scores in traumatic brain injury (TBI). Objective: To investigate whether admission levels of eight different protein biomarkers can improve outcome prediction performance of the Helsinki Computed Tomography Score (HCTS) without clinical covariates in TBI. Materials and methods: Eighty-two patients with computed tomography positive TBIs were included in this study. Plasma levels of β-amyloid isoforms 1-40 (Aβ40) and 1-42 (Aβ42), glial fibrillary acidic protein, heart fatty acid binding protein, interleukin 10 (IL-10), neurofilament light (NF-L), S100B and total tau were measured within 24h from admission. The patients were divided into favorable [Glasgow Outcome Scale-Extended (GOSE) 5–8, n=49] and unfavorable (GOSE 1¬¬–4, n=33) groups. Outcome was assessed 6–12 months after injury. An optimal predictive panel was investigated with sensitivity set at 90–100%. Results: The HCTS alone yielded a sensitivity of 97.0% (95%CI:90.9–100) and specificity of 22.4% (95%CI:10.2–32.7), and partial area under the curve of receiver operating characteristic (pAUC) of 2.5% (95%CI:1.1–4.7), in discriminating patients with favorable and unfavorable outcome. The threshold to detect a patient with unfavorable outcome was a HCTS>1. The three best individually performing biomarkers in outcome prediction were Aβ40, Aβ42 and NF-L. The optimal panel included IL-10, Aβ40 and the HCTS reaching a pAUC of 3.4% (95%CI:1.7–6.2) with a sensitivity of 90.9% (95%CI:81.8–100) and specificity of 59.2% (95%CI:40.8–69.4). Conclusion: Admission plasma levels of IL-10 and Aβ40 significantly improve the prognostication ability of the HCTS following TBI." @default.
• W3097484053 created "2020-11-09" @default.
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• W3097484053 date "2020-10-30" @default.
• W3097484053 modified "2023-10-18" @default.
• W3097484053 title "Admission Levels of Interleukin 10 and Amyloid β 1–40 Improve the Outcome Prediction Performance of the Helsinki Computed Tomography Score in Traumatic Brain Injury" @default.
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• W3097484053 doi "https://doi.org/10.3389/fneur.2020.549527" @default.
• W3097484053 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7661930" @default.
• W3097484053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33192979" @default.
• W3097484053 hasPublicationYear "2020" @default.
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