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- W3097485052 abstract "<b>Introduction:</b> Patients with pulmonary hypertension (PH) require repeat investigation to allow risk stratification and guide optimal therapy. These tests include CT and catheter studies utilising ionising radiation and contrast. Oxygen-enhanced magnetic resonance imaging (OE-MRI) is an alternative technique that provides measures related to regional ventilation, diffusion and perfusion and may provide novel biomarkers of PH severity. <b>Aims:</b> Assess correlation of OE-MRI measures with standard clinical measures of PH severity. <b>Methods:</b> Newly diagnosed group 1 or 4 PH patients underwent OE-MRI, with resultant measures compared with standard of care clinical outputs via Spearman’s correlation. <b>Results:</b> 12 patients were scanned (mean age 54.9±16.6 years old, mean pulmonary artery pressure 41.3±13.9mmHg). Significant correlation was seen between right ventricular (RV) end diastolic volume and median OE-MRI oxygen wash in time (WIT) (r<sub>s</sub>= 0.571, p= 0.048) and WIT interquartile range – a marker of spatial disease heterogeneity (r<sub>s</sub>= 0.857, p= 0.003). The WIT interquartile range also showed a moderate, negative association with RV ejection fraction (r<sub>s</sub>= -0.618, p=0.034). Interquartile range of native lung T<sub>1</sub> relaxation time negatively correlated with TLCO (r<sub>s</sub>= -0.786, p= 0.021). <b>Conclusions:</b> Significant correlations have been demonstrated between OE-MRI measures of gas delivery and established markers of PH severity." @default.
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- W3097485052 date "2020-09-07" @default.
- W3097485052 modified "2023-09-25" @default.
- W3097485052 title "Dynamic oxygen-enhanced magnetic resonance imaging-based quantification of pulmonary hypertension" @default.
- W3097485052 doi "https://doi.org/10.1183/13993003.congress-2020.853" @default.
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