Matches in SemOpenAlex for { <https://semopenalex.org/work/W3097560594> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W3097560594 abstract "Abstract Introduction Human papillomavirus (HPV) vaccination is essential for cervical cancer prevention. However, the value of HPV vaccination in the context excisional treatment of high-grade cervical intraepithelial neoplasia (CIN 3) remains unclear. Methods In this meta-analysis, three retrospective and three prospective studies, three post-hoc analyses of RCTs and one cancer registry study analysing the effect of pre- or post-conization vaccination (bi- or quadrivalent vaccine) against HPV were included after a systematic review of literature. Random-effect models were prepared to evaluate the influence of vaccination on recurrent CIN 2+. Results Primary end point was CIN2+ in every study. The overall study population included 21,059 patients (3,939 vaccinations vs. 17,150 controls). The results showed a significant risk reduction for the development of new high-grade intraepithelial lesions after HPV vaccination (relative risk (RR) 0.41; 95% CI [0.27; 0.64]), independent from HPV type. Due to the heterogeneous study population multiple sub analyses regarding HPV type, age of patients, time of vaccination and follow-up were performed. Age-dependent analysis showed no differences between women under 25 years (RR 0.47 (95%-CI [0.28; 0.80]) and women of higher age (RR 0.52 (95%-CI [0.41; 0.65]). Results for HPV 16/18 positive CIN2+ showed a RR of 0.37 (95% CI [0.17; 0.80]). Overall, the number of women that would have to be vaccinated before or after conization to prevent one case of recurrent CIN 2+ (NNV) is 45.5. Conclusion Meta-analysis showed a significant risk reduction of developing recurrent cervical intraepithelial neoplasia after surgical excision and HPV vaccination compared to surgical excision only." @default.
- W3097560594 created "2020-11-09" @default.
- W3097560594 creator A5001140861 @default.
- W3097560594 creator A5046756822 @default.
- W3097560594 creator A5053977105 @default.
- W3097560594 creator A5056959662 @default.
- W3097560594 creator A5079380861 @default.
- W3097560594 date "2020-10-01" @default.
- W3097560594 modified "2023-09-23" @default.
- W3097560594 title "Prophylactic HPV vaccination after conization: A systematic review and meta-analysis" @default.
- W3097560594 doi "https://doi.org/10.1055/s-0040-1717205" @default.
- W3097560594 hasPublicationYear "2020" @default.
- W3097560594 type Work @default.
- W3097560594 sameAs 3097560594 @default.
- W3097560594 citedByCount "0" @default.
- W3097560594 crossrefType "proceedings-article" @default.
- W3097560594 hasAuthorship W3097560594A5001140861 @default.
- W3097560594 hasAuthorship W3097560594A5046756822 @default.
- W3097560594 hasAuthorship W3097560594A5053977105 @default.
- W3097560594 hasAuthorship W3097560594A5056959662 @default.
- W3097560594 hasAuthorship W3097560594A5079380861 @default.
- W3097560594 hasConcept C121608353 @default.
- W3097560594 hasConcept C126322002 @default.
- W3097560594 hasConcept C151730666 @default.
- W3097560594 hasConcept C203014093 @default.
- W3097560594 hasConcept C22070199 @default.
- W3097560594 hasConcept C2777343196 @default.
- W3097560594 hasConcept C2778220009 @default.
- W3097560594 hasConcept C2778580637 @default.
- W3097560594 hasConcept C2779343474 @default.
- W3097560594 hasConcept C2908647359 @default.
- W3097560594 hasConcept C29456083 @default.
- W3097560594 hasConcept C44249647 @default.
- W3097560594 hasConcept C71924100 @default.
- W3097560594 hasConcept C82789193 @default.
- W3097560594 hasConcept C86803240 @default.
- W3097560594 hasConcept C95190672 @default.
- W3097560594 hasConcept C99454951 @default.
- W3097560594 hasConceptScore W3097560594C121608353 @default.
- W3097560594 hasConceptScore W3097560594C126322002 @default.
- W3097560594 hasConceptScore W3097560594C151730666 @default.
- W3097560594 hasConceptScore W3097560594C203014093 @default.
- W3097560594 hasConceptScore W3097560594C22070199 @default.
- W3097560594 hasConceptScore W3097560594C2777343196 @default.
- W3097560594 hasConceptScore W3097560594C2778220009 @default.
- W3097560594 hasConceptScore W3097560594C2778580637 @default.
- W3097560594 hasConceptScore W3097560594C2779343474 @default.
- W3097560594 hasConceptScore W3097560594C2908647359 @default.
- W3097560594 hasConceptScore W3097560594C29456083 @default.
- W3097560594 hasConceptScore W3097560594C44249647 @default.
- W3097560594 hasConceptScore W3097560594C71924100 @default.
- W3097560594 hasConceptScore W3097560594C82789193 @default.
- W3097560594 hasConceptScore W3097560594C86803240 @default.
- W3097560594 hasConceptScore W3097560594C95190672 @default.
- W3097560594 hasConceptScore W3097560594C99454951 @default.
- W3097560594 hasLocation W30975605941 @default.
- W3097560594 hasOpenAccess W3097560594 @default.
- W3097560594 hasPrimaryLocation W30975605941 @default.
- W3097560594 hasRelatedWork W11223332 @default.
- W3097560594 hasRelatedWork W12924668 @default.
- W3097560594 hasRelatedWork W16045779 @default.
- W3097560594 hasRelatedWork W16483658 @default.
- W3097560594 hasRelatedWork W21306 @default.
- W3097560594 hasRelatedWork W7782771 @default.
- W3097560594 hasRelatedWork W7974339 @default.
- W3097560594 hasRelatedWork W8413834 @default.
- W3097560594 hasRelatedWork W8716149 @default.
- W3097560594 hasRelatedWork W16455150 @default.
- W3097560594 isParatext "false" @default.
- W3097560594 isRetracted "false" @default.
- W3097560594 magId "3097560594" @default.
- W3097560594 workType "article" @default.