FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3097581279> ?p ?o ?g. }

• W3097581279 endingPage "e1009185" @default.
• W3097581279 startingPage "e1009185" @default.
• W3097581279 abstract "Histone acetylation, balanced by histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes, affects dynamic transitions of chromatin structure to regulate transcriptional accessibility. However, little is known about the interplay between HAT and HDAC complexes in Fusarium graminearum , a causal agent of Fusarium Head Blight (FHB) that uniquely contains chromosomal regions enriched for house-keeping or infection-related genes. In this study, we identified the ortholog of the human inhibitor of growth (ING1) gene in F . graminearum ( FNG1 ) and found that it specifically interacts with the FgEsa1 HAT of the NuA4 complex. Deletion of FNG1 led to severe growth defects and blocked conidiation, sexual reproduction, DON production, and plant infection. The fng1 mutant was normal in H3 acetylation but significantly reduced in H4 acetylation. A total of 34 spontaneous suppressors of fng1 with faster growth rate were isolated. Most of them were still defective in sexual reproduction and plant infection. Thirty two of them had mutations in orthologs of yeast RPD3 , SIN3 , and SDS3 , three key components of the yeast Rpd3L HDAC complex. Four mutations in these three genes were verified to suppress the defects of fng1 mutant in growth and H4 acetylation. The rest two suppressor strains had a frameshift or nonsense mutation in a glutamine-rich hypothetical protein that may be a novel component of the FgRpd3 HDAC complex in filamentous fungi. FgRpd3, like Fng1, localized in euchromatin. Deletion of FgRPD3 resulted in severe growth defects and elevated H4 acetylation. In contract, the Fgsds3 deletion mutant had only a minor reduction in growth rate but FgSIN3 appeared to be an essential gene. RNA-seq analysis revealed that 48.1% and 54.2% of the genes with altered expression levels in the fng1 mutant were recovered to normal expression levels in two suppressor strains with mutations in FgRPD3 and FgSDS3 , respectively. Taken together, our data showed that Fng1 is important for H4 acetylation as a component of the NuA4 complex and functionally related to the FgRpd3 HDAC complex for transcriptional regulation of genes important for growth, conidiation, sexual reproduction, and plant infection in F . graminearum ." @default.
• W3097581279 created "2020-11-09" @default.
• W3097581279 creator A5010466999 @default.
• W3097581279 creator A5015540402 @default.
• W3097581279 creator A5017126755 @default.
• W3097581279 creator A5021240812 @default.
• W3097581279 creator A5026260090 @default.
• W3097581279 creator A5031803977 @default.
• W3097581279 creator A5044625929 @default.
• W3097581279 creator A5053044736 @default.
• W3097581279 creator A5067548365 @default.
• W3097581279 creator A5075140707 @default.
• W3097581279 creator A5080052541 @default.
• W3097581279 date "2020-11-02" @default.
• W3097581279 modified "2023-10-14" @default.
• W3097581279 title "Opposing functions of Fng1 and the Rpd3 HDAC complex in H4 acetylation in Fusarium graminearum" @default.
• W3097581279 cites W1534187367 @default.
• W3097581279 cites W1825202194 @default.
• W3097581279 cites W1874881634 @default.
• W3097581279 cites W1913652972 @default.
• W3097581279 cites W1982980973 @default.
• W3097581279 cites W1986073584 @default.
• W3097581279 cites W1989277636 @default.
• W3097581279 cites W1997962605 @default.
• W3097581279 cites W2005928381 @default.
• W3097581279 cites W2012385113 @default.
• W3097581279 cites W2012647856 @default.
• W3097581279 cites W2021375334 @default.
• W3097581279 cites W2022439334 @default.
• W3097581279 cites W2023780637 @default.
• W3097581279 cites W2024549899 @default.
• W3097581279 cites W2035206032 @default.
• W3097581279 cites W2057210248 @default.
• W3097581279 cites W2062412478 @default.
• W3097581279 cites W2076504095 @default.
• W3097581279 cites W2085885847 @default.
• W3097581279 cites W2086088421 @default.
• W3097581279 cites W2087603327 @default.
• W3097581279 cites W2091399085 @default.
• W3097581279 cites W2099154846 @default.
• W3097581279 cites W2102278945 @default.
• W3097581279 cites W2104570606 @default.
• W3097581279 cites W2107277218 @default.
• W3097581279 cites W2108234281 @default.
• W3097581279 cites W2111578933 @default.
• W3097581279 cites W2116085127 @default.
• W3097581279 cites W2117131162 @default.
• W3097581279 cites W2119410736 @default.
• W3097581279 cites W2130163822 @default.
• W3097581279 cites W2131772276 @default.
• W3097581279 cites W2138207763 @default.
• W3097581279 cites W2140602911 @default.
• W3097581279 cites W2141329705 @default.
• W3097581279 cites W2143242138 @default.
• W3097581279 cites W2147380096 @default.
• W3097581279 cites W2147526198 @default.
• W3097581279 cites W2148520503 @default.
• W3097581279 cites W2150310584 @default.
• W3097581279 cites W2152073864 @default.
• W3097581279 cites W2152187233 @default.
• W3097581279 cites W2152701278 @default.
• W3097581279 cites W2157209798 @default.
• W3097581279 cites W2158747282 @default.
• W3097581279 cites W2162865374 @default.
• W3097581279 cites W2162917727 @default.
• W3097581279 cites W2164154943 @default.
• W3097581279 cites W2169315906 @default.
• W3097581279 cites W2170405043 @default.
• W3097581279 cites W2170551349 @default.
• W3097581279 cites W21943246 @default.
• W3097581279 cites W2293000668 @default.
• W3097581279 cites W2329514388 @default.
• W3097581279 cites W2341539131 @default.
• W3097581279 cites W2412666212 @default.
• W3097581279 cites W2544352050 @default.
• W3097581279 cites W2606439016 @default.
• W3097581279 cites W2622413014 @default.
• W3097581279 cites W2788134167 @default.
• W3097581279 cites W2794459666 @default.
• W3097581279 cites W2799886036 @default.
• W3097581279 cites W2809520491 @default.
• W3097581279 cites W2883719988 @default.
• W3097581279 cites W2888489075 @default.
• W3097581279 cites W2898402099 @default.
• W3097581279 cites W2901834665 @default.
• W3097581279 cites W2910465611 @default.
• W3097581279 cites W2946996288 @default.
• W3097581279 cites W2951912016 @default.
• W3097581279 cites W2957222625 @default.
• W3097581279 cites W2959020782 @default.
• W3097581279 cites W2966309627 @default.
• W3097581279 cites W2976773106 @default.
• W3097581279 doi "https://doi.org/10.1371/journal.pgen.1009185" @default.
• W3097581279 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7660929" @default.
• W3097581279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33137093" @default.
• W3097581279 hasPublicationYear "2020" @default.
• W3097581279 type Work @default.
• W3097581279 sameAs 3097581279 @default.

• next