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• W3097650710 abstract "Giardiasis is an infectious disease caused by Giardia duodenalis. The pro-drug metronidazole (MTZ) is the first-line treatment for giardiasis. Parasite’s proteins as pyruvate:ferredoxin oxidoreductase (PFOR), ferredoxin (Fd), nitroreductase-1 (NR-1) and thioredoxin reductase (TrxR) participate in MTZ activation. Here, we showed Giardia trophozoites long-term exposed to MTZ presented higher IC50 than controls, showing the drug influenced the parasite survival. That reduction in MTZ’s susceptibility does not seem to be related to mutations in the genes pfor, fd, nr-1 or trxr. It points that different mechanism as alterations in other metabolic pathways can account for Giardia resistance to MTZ therapy." @default.
• W3097650710 created "2020-11-09" @default.
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• W3097650710 date "2020-01-01" @default.
• W3097650710 modified "2023-10-16" @default.
• W3097650710 title "In vitro-induction of metronidazole-resistant Giardia duodenalis is not associated with nucleotide alterations in the genes involved in pro-drug activation" @default.
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• W3097650710 doi "https://doi.org/10.1590/0074-02760200303" @default.
• W3097650710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7607557" @default.
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