FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3097656348> ?p ?o ?g. }

• W3097656348 abstract "Abstract Background Brown adipose tissue (BAT) is a fat tissue found in most mammals that helps regulate energy balance and core body temperature through a sympathetic process known as non-shivering thermogenesis. BAT activity is commonly detected and quantified in [ 18 F]FDG positron emission tomography/computed tomography (PET/CT) scans, and radiotracer uptake in BAT during adrenergic stimulation is often used as a surrogate measure for identifying thermogenic activity in the tissue. BAT thermogenesis is believed to be contingent upon the expression of the protein UCP1, but conflicting results have been reported in the literature concerning [ 18 F]FDG uptake within BAT of mice with and without UCP1. Differences in animal handling techniques such as feeding status, type of anesthetic, type of BAT stimulation, and estrogen levels were identified as possible confounding variables for [ 18 F]FDG uptake. In this study, we aimed to assess differences in BAT [ 18 F]FDG uptake between wild-type and UCP1-knockout mice using a protocol that minimizes possible variations in BAT stimulation caused by different stress responses to mouse handling. Results [ 18 F]FDG PET/CT scans were run on mice that were anesthetized with pentobarbital after stimulation of non-shivering thermogenesis by norepinephrine. While in wild-type mice [ 18 F]FDG uptake in BAT increased significantly with norepinephrine stimulation of BAT, there was no consistent change in [ 18 F]FDG uptake in BAT of mice lacking UCP1. Conclusions [ 18 F]FDG uptake within adrenergically stimulated BAT of wild-type and UCP1-knockout mice can significantly vary such that an [ 18 F]FDG uptake threshold cannot be used to differentiate wild-type from UCP1-knockout mice. However, while an increase in BAT [ 18 F]FDG uptake during adrenergic stimulation is consistently observed in wild-type mice, in UCP1-knockout mice [ 18 F]FDG uptake in BAT seems to be independent of β 3 -adrenergic stimulation of non-shivering thermogenesis." @default.
• W3097656348 created "2020-11-09" @default.
• W3097656348 creator A5004559356 @default.
• W3097656348 creator A5004894284 @default.
• W3097656348 creator A5019307605 @default.
• W3097656348 creator A5029995135 @default.
• W3097656348 creator A5038430305 @default.
• W3097656348 creator A5053226406 @default.
• W3097656348 creator A5056405812 @default.
• W3097656348 date "2020-11-07" @default.
• W3097656348 modified "2023-10-17" @default.
• W3097656348 title "Differences in [18F]FDG uptake in BAT of UCP1 −/− and UCP1 +/+ during adrenergic stimulation of non-shivering thermogenesis" @default.
• W3097656348 cites W1803150633 @default.
• W3097656348 cites W1965079305 @default.
• W3097656348 cites W1966524153 @default.
• W3097656348 cites W1969210192 @default.
• W3097656348 cites W1981298061 @default.
• W3097656348 cites W1986333814 @default.
• W3097656348 cites W2001920781 @default.
• W3097656348 cites W2006361510 @default.
• W3097656348 cites W2009646528 @default.
• W3097656348 cites W2020666251 @default.
• W3097656348 cites W2050081916 @default.
• W3097656348 cites W2057683888 @default.
• W3097656348 cites W2064339084 @default.
• W3097656348 cites W2064939678 @default.
• W3097656348 cites W2066357535 @default.
• W3097656348 cites W2093176289 @default.
• W3097656348 cites W2115989405 @default.
• W3097656348 cites W2131762758 @default.
• W3097656348 cites W2132358997 @default.
• W3097656348 cites W2148400263 @default.
• W3097656348 cites W2159444491 @default.
• W3097656348 cites W2167372092 @default.
• W3097656348 cites W2168695748 @default.
• W3097656348 cites W2292171573 @default.
• W3097656348 cites W2396954935 @default.
• W3097656348 cites W2474827673 @default.
• W3097656348 cites W2573433180 @default.
• W3097656348 cites W2581668386 @default.
• W3097656348 cites W2599256416 @default.
• W3097656348 cites W2641602479 @default.
• W3097656348 cites W2736913806 @default.
• W3097656348 cites W2741061140 @default.
• W3097656348 cites W2789369115 @default.
• W3097656348 cites W2885192168 @default.
• W3097656348 cites W2888721649 @default.
• W3097656348 cites W2901718336 @default.
• W3097656348 cites W2980740621 @default.
• W3097656348 doi "https://doi.org/10.1186/s13550-020-00726-x" @default.
• W3097656348 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7648812" @default.
• W3097656348 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33159596" @default.
• W3097656348 hasPublicationYear "2020" @default.
• W3097656348 type Work @default.
• W3097656348 sameAs 3097656348 @default.
• W3097656348 citedByCount "5" @default.
• W3097656348 countsByYear W30976563482022 @default.
• W3097656348 countsByYear W30976563482023 @default.
• W3097656348 crossrefType "journal-article" @default.
• W3097656348 hasAuthorship W3097656348A5004559356 @default.
• W3097656348 hasAuthorship W3097656348A5004894284 @default.
• W3097656348 hasAuthorship W3097656348A5019307605 @default.
• W3097656348 hasAuthorship W3097656348A5029995135 @default.
• W3097656348 hasAuthorship W3097656348A5038430305 @default.
• W3097656348 hasAuthorship W3097656348A5053226406 @default.
• W3097656348 hasAuthorship W3097656348A5056405812 @default.
• W3097656348 hasBestOaLocation W30976563481 @default.
• W3097656348 hasConcept C126322002 @default.
• W3097656348 hasConcept C134018914 @default.
• W3097656348 hasConcept C151279926 @default.
• W3097656348 hasConcept C158453852 @default.
• W3097656348 hasConcept C170493617 @default.
• W3097656348 hasConcept C171089720 @default.
• W3097656348 hasConcept C24998067 @default.
• W3097656348 hasConcept C2780642333 @default.
• W3097656348 hasConcept C2781258859 @default.
• W3097656348 hasConcept C42219234 @default.
• W3097656348 hasConcept C71924100 @default.
• W3097656348 hasConcept C81979416 @default.
• W3097656348 hasConceptScore W3097656348C126322002 @default.
• W3097656348 hasConceptScore W3097656348C134018914 @default.
• W3097656348 hasConceptScore W3097656348C151279926 @default.
• W3097656348 hasConceptScore W3097656348C158453852 @default.
• W3097656348 hasConceptScore W3097656348C170493617 @default.
• W3097656348 hasConceptScore W3097656348C171089720 @default.
• W3097656348 hasConceptScore W3097656348C24998067 @default.
• W3097656348 hasConceptScore W3097656348C2780642333 @default.
• W3097656348 hasConceptScore W3097656348C2781258859 @default.
• W3097656348 hasConceptScore W3097656348C42219234 @default.
• W3097656348 hasConceptScore W3097656348C71924100 @default.
• W3097656348 hasConceptScore W3097656348C81979416 @default.
• W3097656348 hasFunder F4320337357 @default.
• W3097656348 hasIssue "1" @default.
• W3097656348 hasLocation W30976563481 @default.
• W3097656348 hasLocation W30976563482 @default.
• W3097656348 hasLocation W30976563483 @default.
• W3097656348 hasLocation W30976563484 @default.
• W3097656348 hasLocation W30976563485 @default.
• W3097656348 hasLocation W30976563486 @default.
• W3097656348 hasOpenAccess W3097656348 @default.

• next