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• W3097657088 abstract "Background and objectives Head and neck dermatitis (HND) is a clinical variant of atopic dermatitis (AD), presenting in adolescence or adulthood and characterized by involvement of the head, neck, and superior part of the trunk. The role of Malassezia spp has been advocated in the pathogenesis of HND, and antifungal agents represent the treatment of choice. Methods A retrospective single-center study was performed to define the clinical features and treatment response of HND among adolescent and adult patients. Results Thirty-one patients were identified, 17 with adolescent-onset and 14 with adult-onset HND. Adolescent-onset HND positively correlated with a past history of AD and presented with exclusive head and neck involvement (P < .05). Adult-onset HND was associated with concomitant widespread atopic eczema, involving the flexural areas of the upper and lower limbs, trunk, nipples, or hands (P < .05). A positive response to itraconazole in combination with topical treatments was observed in both groups. Conclusions This study delineates two HND clinical phenotypes: adolescent vs adult onset. Different characteristics were observed in terms of relationship to AD and eczema localization. A history of AD in childhood and presentation with exclusive involvement of head and neck regions was observed predominantly in the adolescent-onset form, while adult-onset HND often occurred in association with diffuse dermatitis and a past history of AD was less frequent than in the adolescent group. The study is limited by the single-center retrospective nature, which may lead to diagnostic and selection biases, and the small cohort of patients." @default.
• W3097657088 created "2020-11-09" @default.
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• W3097657088 date "2020-11-06" @default.
• W3097657088 modified "2023-10-05" @default.
• W3097657088 title "Head and neck dermatitis, a subtype of atopic dermatitis induced by <i>Malassezia</i> spp: Clinical aspects and treatment outcomes in adolescent and adult patients" @default.
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• W3097657088 doi "https://doi.org/10.1111/pde.14437" @default.
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