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- W3097660308 endingPage "2402" @default.
- W3097660308 startingPage "2402" @default.
- W3097660308 abstract "Cells comprise several intracellular membrane compartments that allow them to function properly. One of these functions is cargo movement, typically proteins and membranes within cells. These cargoes ride microtubules through vesicles from Golgi and recycling endosomes to the plasma membrane in order to be delivered and exocytosed. In neurons, synaptic functions employ this cargo trafficking to maintain inter-neuronal communication optimally. One of the complexes that oversee vesicle trafficking and tethering is the exocyst. The exocyst is a protein complex containing eight subunits first identified in yeast and then characterized in multicellular organisms. This complex is related to several cellular processes, including cellular growth, division, migration, and morphogenesis, among others. It has been associated with glutamatergic receptor trafficking and tethering into the synapse, providing the molecular machinery to deliver receptor-containing vesicles into the plasma membrane in a constitutive manner. In this review, we discuss the evidence so far published regarding receptor trafficking and the exocyst complex in both basal and stimulated levels, comparing constitutive trafficking and long-term potentiation-related trafficking." @default.
- W3097660308 created "2020-11-09" @default.
- W3097660308 creator A5001286211 @default.
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- W3097660308 creator A5040876102 @default.
- W3097660308 creator A5045733795 @default.
- W3097660308 creator A5057013208 @default.
- W3097660308 date "2020-11-03" @default.
- W3097660308 modified "2023-09-30" @default.
- W3097660308 title "Glutamatergic Receptor Trafficking and Delivery: Role of the Exocyst Complex" @default.
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