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- W3097675556 abstract "The influence of DNA methylation on gene behavior and its consequent phenotypic effects appear to be very important, but the details are not well understood. Insects offer a diversity of DNA methylation modes, making them an excellent lineage for comparative analyses. However, functional studies have tended to focus on quite specialized holometabolan species, such as wasps, bees, beetles, and flies. Here, we have studied DNA methylation in the hemimetabolan insect Blattella germanica. In this cockroach, a gene involved in DNA methylation, DNA methyltransferase 1 (DNMT1), is expressed in early embryogenesis. In our experiments, RNAi of DNMT1 reduces DNA methylation and impairs blastoderm formation. Using reduced representation bisulfite sequencing and transcriptome analyses, we observed that methylated genes are associated with metabolism and are highly expressed, whereas unmethylated genes are related to signaling and show low expression. Moreover, methylated genes show greater expression change and less expression variability than unmethylated genes." @default.
- W3097675556 created "2020-11-09" @default.
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- W3097675556 date "2020-12-01" @default.
- W3097675556 modified "2023-10-16" @default.
- W3097675556 title "DNMT1 Promotes Genome Methylation and Early Embryo Development in Cockroaches" @default.
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- W3097675556 doi "https://doi.org/10.1016/j.isci.2020.101778" @default.
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